Unlock instant, AI-driven research and patent intelligence for your innovation.
Application of vitamin D analogue for treating or preventing viral hepatitis
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for viral hepatitis and derivatives, applied in antiviral agents, drug combinations, organic active ingredients, etc., to achieve excellent clinical safety, excellent pharmacokinetic properties, and good druggability
Pending Publication Date: 2022-03-22
HOLY HAID LAB CORP
View PDF3 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
The point is that there is still no drug that can completely clear the virus and achieve a functional cure for hepatitis B
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0109] Example 1 - Application of HepG2-NTCP cells to evaluate the in vitro anti-HBV activity of paricalcitol (HD009, compound 9), alfacalcitol (HD125, compound 18) and calcifediol (HD135, compound 3)
[0110] Compound preparation method is as follows:
[0111] Take the preparation of 20mM concentration as an example, the volume of solvent DMSO (μl) = sample mass (mg) × purity ÷ molecular weight ÷ 20 × 10 6
[0112] Control compounds include ETV (Entecavir) (batch number: P1214012; 99.0% purity), purchased from Shanghai Titan Technology Co., Ltd.; HD131 (vitamin D2), HD132 (vitamin D3), HD134 (docalcitol), purchased from Shanghai Tao Su Biochemical Technology Co., Ltd. The concentration of the stock solutions of the above control compounds was 20 mM and stored at -20°C.
[0117] On day 0, HepG2-NTCP was plated into 48-well plates (7....
Embodiment 2-A
[0153] Embodiment 2-AAV HBV mouse model experiment
[0154]Administration was carried out according to the following table 7, and the content of HBV DNA, HBeAg and HBsAg in the cell culture supernatant was detected with reference to the same method as above, and the results are shown in Table 8:
[0155] Table 7
[0156] way of administration time blank 0, once a day 7 days HD125 2ug / kg, once a day 7 days
[0159] Animal experiment results also show that HD125 (alfacalcidol) can effectively reduce HBV DNA, HBsAg and HBeAg, showing good antiviral effect in vivo.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The present invention relates to the use of vitamin D analogs for the treatment or prevention of viral hepatitis. Specifically, the invention provides a compound as shown in a general formula 1 or pharmaceutically acceptable salt thereof, and application of the compound or the pharmaceutically acceptable salt in treating or preventing viral hepatitis. Preferably, the viral hepatitis is hepatitis B. The invention also provides a pharmaceutical composition for treating or preventing viral hepatitis, which comprises the compound as shown in the general formula 1 or pharmaceutically acceptable salt thereof, one or more optional additional therapeutic or prophylactic agents, and a pharmaceutically acceptable carrier.
Description
[0001] This application claims priority to the prior application filed with the State Intellectual Property Office of China on January 10, 2021, with patent application number 202110027380.8, entitled "Application of Vitamin D Analogues for the Treatment or Prevention of Viral Hepatitis" . The entirety of this prior application is incorporated by reference into the present application. technical field [0002] The invention relates to the technical field of antiviral drugs, in particular to a pharmaceutical composition for treating or preventing viral hepatitis and its application. Background technique [0003] Human hepatitis B virus (HBV) infection is an important public health problem worldwide. After acute hepatitis B virus infection, about 8% still develop into chronic hepatitis B infection, and persistent HBV infection will lead to liver cirrhosis and even liver cancer. Although the new hepatitis Binfection rate has been effectively controlled with the widespread po...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More 
