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Nanometer material with asymmetric structure as well as preparation method and application of nanometer material

A technology of asymmetric structure and nanomaterials, applied in the field of asymmetric structure nanomaterials and its preparation, can solve the problems of short retention time and poor drug penetration ability, and achieve simple preparation method, enhancement and retention, and improvement of drug treatment effect Effect

Pending Publication Date: 2022-03-25
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects of poor drug penetration and short retention time in local treatment, provide a method and platform for improving drug penetration and retention, and provide new ideas and means for traumatic injury treatment

Method used

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  • Nanometer material with asymmetric structure as well as preparation method and application of nanometer material
  • Nanometer material with asymmetric structure as well as preparation method and application of nanometer material
  • Nanometer material with asymmetric structure as well as preparation method and application of nanometer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 (JCNs)

[0043] A preparation method of an asymmetric structure nano material, comprising the following steps:

[0044] S1: Preparation of carbon nanospheres:

[0045] Firstly, 1.029 g of glucose was dissolved in 20 mL of deionized water, then transferred to a 25 mL hydrothermal synthesis reactor, heated to 180 °C and maintained for 3 h. Finally, unreacted glucose was removed by centrifugation and multiple water washes to obtain carbon nanospheres.

[0046] S2: the preparation of multi-metal coating:

[0047] First, disperse the carbon nanospheres obtained in the previous step in alcohol, and drop them on the silicon wafer to obtain carbon nanospheres distributed in a single layer. The obtained carbon nanospheres were subjected to scanning electron microscope analysis. like figure 1 As shown, the results of scanning electron microscopy prove that the obtained carbon nanospheres are regular spherical, with a particle size of about 106 nm, and are distribut...

Embodiment 2

[0049] Example 2 (Pt-CNs)

[0050] The difference from Example 1 is that its metal coating only has platinum element.

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Abstract

The invention belongs to the technical field of nano biological new materials, and particularly relates to an asymmetric structure nano material and a preparation method and application thereof, and the asymmetric structure nano material comprises a nano particle core without catalytic activity and a metal coating; and the metal coating is only distributed on one side of the nanoparticle core without catalytic activity. The preparation method has the beneficial effects that a new thought for enhancing medicine permeation and retention is provided; meanwhile, the invention provides a nano material with an asymmetric structure, which can be used for trauma treatment. Due to the modular design, the self-driven platform can be easily transformed into a delivery carrier capable of loading various clinical medicines, the medicines are assisted to reach deep tissues to play a role, and the treatment effect of the medicines is improved; the preparation method is simple.

Description

technical field [0001] The invention belongs to the technical field of new nano-biological materials, and relates to a nano-material with an asymmetric structure, a preparation method and an application thereof. Background technique [0002] Traumatic injury is the destruction of human tissues or organs caused by mechanical factors. It is common in wars, natural disasters, traffic accidents, falls from high altitudes, sports, etc. Its onset is sudden and cannot be prevented in advance, and it seriously threatens human life and health. According to the classification of injured parts, trauma can be divided into craniocerebral trauma, chest trauma, abdominal trauma, fractures and dislocations of various parts, hand injuries, etc. According to the pathological process, trauma can usually be divided into two distinct phases: primary injury and secondary injury. Secondary injuries are the leading cause of patient death in hospital. A few minutes after the trauma occurs, a large...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/02A61P17/02A61P29/00A61P39/06B82Y5/00B82Y40/00
CPCA61K47/02A61P17/02A61P29/00A61P39/06B82Y5/00B82Y40/00
Inventor 薛雪王和平
Owner NANKAI UNIV