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Biosensor

A biosensor, electrode technology, applied in the field of detection, can solve the problems of not covering the working electrode, wrong judgment, inaccurate detection results, etc.

Pending Publication Date: 2022-04-01
LEADWAY HK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the edges on both sides of the sampling channel are made of hydrophilic materials, sometimes the liquid surface at the forefront of the sample in the sampling channel will be concave, especially when the sampling channel is relatively wide. The front end touches the third electrode first, and the middle end of the meniscus does not cover the working electrode
Since the front ends of both sides of the meniscus have touched the third electrode, a loop has been formed between the third electrode and the other electrode that is paired with it. Misjudgment that the amount is sufficient, resulting in inaccurate test results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1 Biosensor Error Reporting Accuracy Experiment for Insufficient Sample Volume

[0093] A biosensor for measuring uric acid content in blood, the biosensor adopts figure 1 and 2In the biosensor structure shown, the sample volume judging electrode does not touch the two sides of the sample injection channel, the length of the working electrode: 3.2mm, the length of the counter electrode: 2.2mm, the width of the sample volume judging electrode (L3): 1.6mm , length: 0.6mm, the width of the sampling channel is 2.3mm, the distance between the two ends of the sample addition judgment electrode and the inner side of the sampling passage is 0.35mm, and the distance between the counter electrode and the sample addition judgment electrode is 0.65mm mm. The reagents on the working electrode and the counter electrode include reagents such as buffer solutions, polymers, and mediators. The test instrument applies a 0.4V DC voltage between the working electrode and the samp...

Embodiment 2

[0104] Sample amount experiment of embodiment 2 different temperatures

[0105] Because the temperature also has a relatively obvious influence on the speed of the sample entering the sampling channel. Therefore this embodiment is on the basis of embodiment 1, to figure 1 biosensors and Figure 7 At different temperatures (2.5°C, 10.0°C, 21.0°C, 40.0°C, 47.5°C), samples with different hematocrit (10%, 42%, 70%) were added with the sample volume V2, namely 2.7 μL. To the test strip sample chamber, each condition was tested 100 times. The experimental results are shown in Table 4 and Table 5 below. Experiments have shown that at different temperatures, figure 1 The test accuracy of biosensors is significantly higher than Figure 7 biosensors. Even at different temperatures, the sample volume judgment electrode that is not in contact with the sample injection channel can greatly avoid the risk of instrument misjudgment due to insufficient sample volume.

[0106] Table four...

Embodiment 3

[0112] Embodiment 3 test accuracy experiment

[0113] use figure 1 The indicated biosensors were tested for accuracy experiments.

[0114] Blood samples containing uric acid concentrations of 250 μmol / L, 500 μmol / L, 700 μmol / L, and 1050 μmol / L were added to the present invention at ambient temperatures of 7.5°C, 21°C and 42.5°C. figure 1 The detection was carried out in the biosensor shown, and the sample volume required by the test strip was 3.0 μL. The results are shown in Table 6 below. Experiments show that the biosensor of the present invention has less deviation from the Mindray BS-350E automatic biochemical tester in each concentration range of the uric acid test, and has better test stability.

[0115] Table 6 Uric acid test accuracy experiment

[0116]

[0117]

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Abstract

The invention relates to a biosensor capable of judging whether the sample adding amount is sufficient or not. The biosensor at least comprises an insulating substrate, a working electrode and a sample adding amount judging electrode, the sample adding amount judging electrode is farther away from a sample inlet of the biosensor compared with the working electrode, and the sample adding amount judging electrode is not in contact with a sample inlet channel. The biosensor provided by the invention can judge whether the sample size added on the biosensor meets the detection requirement or not, so that the risk caused by insufficient sample size is effectively avoided, and the accuracy of a test result is ensured.

Description

technical field [0001] The invention relates to the field of detection, in particular to a biosensor for detection. Background technique [0002] A biosensor (biosensor) can usually measure analytes in biological samples such as blood, urine or saliva, and use a tester to convert the electrical signal measured by the biosensor into the content of the analyte in the biological sample. At present, biosensors have been widely used in hospitals or homes, and can detect analytes such as blood sugar, cholesterol, uric acid, triglycerides, lactic acid, ketone bodies, enzymes, creatinine, or urea in biological samples. [0003] Biosensors generally include an insulating substrate, a working electrode and a counter electrode built on the insulating substrate, the working electrode and the counter electrode can be called an electrode system, a reagent solution layer covering the electrode system, and a hydrophilic film layer on the solution layer , a cover slip with air holes is past...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416G01N27/30G01F23/22
CPCG01N27/3272G01F23/242G01F23/265G01F23/268B01L3/502715B01L2300/0645B01L2300/0681G01N27/3275
Inventor 张昱李静曾晓旭张莉孙隽
Owner LEADWAY HK
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