Fetal bovine dermal matrix dressing and preparation method thereof

A dermal matrix, fetal bovine technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of high immunogenicity, easy delamination, poor mechanical properties, etc., and achieve good biocompatibility, antibacterial and bacteriostatic properties. Long-lasting, excellent physical and mechanical properties

Pending Publication Date: 2022-04-05
成都科乐金生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The animal skin in the prior art is mainly pigskin, which has a wide range of sources, and its composition and structure are very similar to human skin. Contamination, when used as a dressing, it is susceptible to bacterial infection and causes wound infection, which limits its clinical application

Method used

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  • Fetal bovine dermal matrix dressing and preparation method thereof
  • Fetal bovine dermal matrix dressing and preparation method thereof
  • Fetal bovine dermal matrix dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Present embodiment 1 provides a kind of preparation method of fetal bovine dermal matrix dressing, comprises the following steps:

[0036] (1) Raw material preparation: take the purified fetal bovine leather, weigh it accurately, and use it as the calculation basis for the following steps.

[0037] (2) Soaking: carried out in an ultrasonic drum. First, put 100 parts by weight of purified fetal bovine leather in an ultrasonic drum, add ultrapure water with a tare weight of 200%, rotate for 5 minutes, soak for 60 minutes, rotate for 30 minutes, and drain water.

[0038] (3) Cross-linking modification: add 80% of ultrapure water to the ultrasonic drum, adjust the internal temperature of the drum to 25°C, add 4% oxidized chitosan quaternary ammonium salt, rotate for 60 minutes, and detect the shrinkage temperature of the skin. It is required that the shrinkage temperature reaches above 70°C. After the shrinkage temperature of the skin reaches the requirement, drain the flu...

Embodiment 2

[0048] Present embodiment 2 provides a kind of preparation method of fetal bovine dermal matrix dressing, comprises the following steps:

[0049] (1) Raw material preparation: take the purified fetal bovine leather, weigh it accurately, and use it as the calculation basis for the following steps.

[0050] (2) Soaking: carried out in an ultrasonic drum. First, put 100 parts by weight of purified fetal bovine leather in an ultrasonic drum, add ultrapure water with a tare weight of 200%, rotate for 5 minutes, soak for 120 minutes, rotate for 30 minutes, and drain water.

[0051] (3) Cross-linking modification: add 140% ultrapure water to the ultrasonic drum, adjust the internal temperature of the drum to 33°C, add 6% oxidized chitosan quaternary ammonium salt, rotate for 120 minutes, and detect the shrinkage temperature of the skin. The shrinkage temperature is required to be above 70°C. After the shrinkage temperature reaches the requirement, drain the liquid.

[0052] (4) Cl...

Embodiment 3

[0061] Present embodiment 3 provides a kind of preparation method of fetal bovine dermal matrix dressing, comprises the following steps:

[0062] (1) Raw material preparation: take the purified fetal bovine leather, weigh it accurately, and use it as the calculation basis for the following steps.

[0063] (2) Soaking: carried out in an ultrasonic drum. First, put 100 parts by weight of purified fetal bovine leather in an ultrasonic drum, add ultrapure water with a tare weight of 200%, rotate for 5 minutes, soak for 180 minutes, rotate for 30 minutes, and drain water.

[0064] (3) Cross-linking modification: Add 200% ultrapure water to the ultrasonic drum, and add 8% oxidized chitosan quaternary ammonium salt into the drum when the internal temperature reaches 40°C, and rotate for 180 minutes to detect the shrinkage temperature of the skin, and the shrinkage is required When the temperature reaches above 70°C, drain the liquid after the shrinkage temperature reaches the requir...

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Abstract

The invention provides a fetal calf dermis matrix dressing and a preparation method thereof.The preparation method comprises the steps that purified fetal calf dermis serves as a raw material, under the ultrasonic condition, the purified fetal calf dermis is put into an ultrasonic rotary drum, after soaking is conducted, cross-linking modification is conducted on the purified fetal calf dermis through oxidized chitosan quaternary ammonium salt, then dialdehyde-beta-cyclodextrin and tea tree oil are added, and the fetal calf dermis matrix dressing is obtained. And carrying out antibacterial and bacteriostatic modification. Finally, after repeated cleaning, centrifugal dewatering, freeze drying, forming, packaging and irradiation are conducted, and the fetal calf dermis matrix dressing with the lasting antibacterial and bacteriostatic function is obtained. The fetal calf dermal matrix dressing prepared by the invention has the characteristics of good biocompatibility, excellent physical and mechanical properties and lasting antibacterial and bacteriostatic properties, has a healing promoting function, and is an ideal high-end dressing.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a fetal bovine dermis matrix dressing and a preparation method thereof. Background technique [0002] Medical dressing is a kind of medical material used to cover the wound surface. During the healing process, the wound surface needs to be covered with an appropriate covering on the wound surface. During the wound healing process, it can replace the damaged skin to obtain a certain protection and avoid or control infection. Wound microenvironment refers to the humidity, temperature, acid-base pH value and low oxygen tension of the wound surface. Therefore, how to create an ideal microenvironment for the wound is the key to choosing a suitable dressing. The ideal dressing should have the following characteristics: keep the wound at a stable temperature and humidity, absorb excess exudate; have good permeability; prevent microorganisms, harmful particles and other harmfu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/42A61L15/46
Inventor 但卫华但晔曾睿
Owner 成都科乐金生物科技有限责任公司
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