Immunodiagnosis kit for active tuberculosis
A technology for active pulmonary tuberculosis and immunodiagnosis, applied in the field of serological immunodiagnosis, can solve problems such as unsatisfactory results, and achieve the effects of preventing sample penetration, improving sensitivity, and improving aging
Pending Publication Date: 2022-04-05
SHIHEZI UNIVERSITY
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Problems solved by technology
With regard to immunological methods, in recent years, certain progress has been made in technologies such as γ-interferon release test, adenosine deaminase (ADA) combined with IGRAs, and flow cytometry analysis of T cell-specific antigens. None of the serological methods for the diagnosis of tuberculosis can achieve satisfactory results
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Embodiment 1
[0021] Such as Figure 1-3 As shown, the present invention provides an immunodiagnostic kit for active pulmonary tuberculosis, comprising a serum sample and a kit body 1, one side of the kit body 1 is provided with an A reagent area 2 and a B reagent area 3, and the A reagent area 2 and The front side of the B reagent area 3 is provided with a partition 4 , the bottoms of the A reagent area 2 and the B reagent area 3 are provided with an impervious plate 5 , and the inside of the A reagent area 2 and the B reagent area 3 is provided with a protein chip.
[0022] Further, the A reagent area 2 and the B reagent area 3 include at least one of TB-CHECK-1 reagent, BATAC MG IT960 reagent, ESAT-6 protein, cytokine I-309, MIG or IL-8, and the A reagent area 2 It is designed as an independent space from the B reagent area 3, and the A reagent area 2 and the B reagent area 3 are on the same plane.
[0023] A reagent zone 2 and B reagent zone 3 quantify at least one of TB-CHECK-1 reagen...
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The present invention discloses an active tuberculosis immunodiagnosis kit, which comprises a serum sample and a kit main body, one side of the kit main body is provided with an A reagent region and a B reagent region, the front sides of the A reagent region and the B reagent region are provided with separation plates, and the bottoms of the A reagent region and the B reagent region are provided with anti-permeation plates. A placed sample is isolated from air through the partition plate, the sample is prevented from being in contact with the air to change, the sample is prevented from permeating through the impermeable plate, the sample is convenient to replace, the shell of the kit main body can be repeatedly used, different or same reagents can be used through the reagent A area and the reagent B area, rapid diagnosis can be carried out, and the detection efficiency is improved. According to the present invention, with the research, the time efficiency of the detection work is improved, the scientific basis is provided for the monitoring of the infectious tuberculosis, and the non-infected population and the active tuberculosis patient can be effectively and rapidly distinguished through the simultaneous detection of the multiple reagents.
Description
technical field [0001] The invention relates to the field of serological immunodiagnosis, in particular to an immunodiagnostic kit for active pulmonary tuberculosis. Background technique [0002] Tuberculosis (TB) is an infectious disease mainly transmitted through the respiratory tract caused by Mycobacterium tuberculosis (MTB), and it is a chronic infectious disease with the highest single-cause mortality rate. Mycobacterium tuberculosis can invade various organs of the human body, but mainly invades the lungs, which is called pulmonary tuberculosis. By the late 1980s, due to factors such as poverty, AIDS, population mobility, and drug resistance, the incidence and mortality of tuberculosis rose rapidly around the world, becoming the most serious infectious disease in the world alongside AIDS. According to World Health Organization (WHO) estimates, about 1 / 3 of the world's population is tuberculosis carriers, and about 5-10% of the carriers can develop into active pulmona...
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IPC IPC(8): G01N33/569
Inventor 李青青章乐王新敏乔春林张署军勾璇李垚
Owner SHIHEZI UNIVERSITY