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Application of gamboge and disulfiram composition in preparation of medicine for treating colon cancer

A technology for disulfiram and colon cancer, which is applied to the application field of a combination of garcinia cambogia and disulfiram in the preparation of a drug for treating colon cancer, can solve the problems of easy generation of drug resistance and high toxicity, and achieves improved pharmacokinetics , reduce the dosage, improve the effect

Active Publication Date: 2022-04-12
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapy is the main treatment for colorectal cancer metastases, but the current clinical first-line chemotherapy drugs for the treatment of colorectal cancer liver metastases are highly toxic and prone to drug resistance (especially for patients with KRAS gene mutations). second-line therapy for

Method used

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  • Application of gamboge and disulfiram composition in preparation of medicine for treating colon cancer
  • Application of gamboge and disulfiram composition in preparation of medicine for treating colon cancer
  • Application of gamboge and disulfiram composition in preparation of medicine for treating colon cancer

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specific Embodiment approach 1

[0024] Specific embodiment one: the application of the combination of Garcinia cambogia and disulfiram in the preparation of drugs for the treatment of colon cancer in this embodiment.

specific Embodiment approach 2

[0025] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the composition of garcinia cambogia and disulfiram consists of garcinia cambogia and disulfiram in a mass ratio of 1:3-4. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0026] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the composition of Garcinia Cambogia and Disulfiram consists of Garcinia Cambogia and Disulfiram in a mass ratio of 1:3.5. Other steps are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses application of a gamboge and disulfiram composition in preparation of a medicine for treating colon cancer, and relates to application of the gamboge and disulfiram composition in preparation of the medicine for treating the colon cancer. The invention aims to provide a low-toxicity second-line therapeutic drug after a first-line therapeutic drug for treating liver metastasis of intestinal cancer is resistant to drugs. A mouse colorectal cancer CT26.WT cell with a mutated KRAS gene is planted in the spleen of a mouse to establish a colorectal cancer liver metastasis model, the effect of the gamboge and disulfiram combined drug in treating colorectal cancer liver metastasis is studied, gambogic acid and disulfiram metabolite diethyl thiocarbamic acid can be subjected to a Michael addition reaction in gastric juice, a fat-soluble compound is formed, the lipid-soluble compound can be used for treating colorectal cancer liver metastasis, and the effect of treating colorectal cancer liver metastasis is achieved. The gambogic acid is not easy to be discharged out of a body, the pharmacokinetics of the gambogic acid is improved, the gambogic acid can be reduced into gambogic acid through in-vivo metabolism, and the effect of synergistically resisting intestinal cancer liver The gamboge and the disulfiram can achieve a synergistic effect, and the anti-tumor effect is remarkably improved. The method is applied to the field of medicine preparation.

Description

technical field [0001] The invention relates to the application of a combination of gamboge and disulfiram in the preparation of medicines for treating colon cancer. Background technique [0002] Colon cancer (colorectal cancer, CRC) is one of the most common malignant tumors. About 40% of colon cancers have KRAS gene mutations. The efficacy of chemotherapy is poor, which seriously endangers human health. The most common metastatic organ of colorectal cancer is the liver. 15%-25% of patients have already metastasized to the liver when they are diagnosed, and another 25%-50% of patients will develop liver metastases within three years after surgery. Chemotherapy is the main treatment for colorectal cancer metastases, but the current clinical first-line chemotherapy drugs for the treatment of colorectal cancer liver metastases are highly toxic and prone to drug resistance (especially for patients with KRAS gene mutations). second-line treatment drugs. Contents of the invent...

Claims

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Application Information

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IPC IPC(8): A61K36/38A61K31/145A61P35/00A61P1/00A61P35/04
Inventor 姜守刚张东魏亮態彬张思艳李汶罡
Owner NORTHEAST FORESTRY UNIVERSITY
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