JZ-NSMD001 organic solution
An organic solution and solution technology, which is applied in the field of chemical engineering, can solve problems such as sticking to stimulate skin health, operator's breathing discomfort, strong irritation and toxicity, etc., and achieve excellent physical, chemical and toxicological safety and good chemical stability , good effect of stable volatility
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Embodiment 1 and 2
[0025] In Examples 1 and 2 below:
[0026] The purity of trifluorotrichloroethane, 2,2,4,6,6-pentamethylheptane, 2,2,7,7-tetramethyloctane, n-dodecane and ethanol used are all commercially pure.
[0027] Relate to test as follows in the embodiment:
[0028] 1. Toxicity test——Shanghai Institute of Chemical Industry Testing Co., Ltd. issued a test report
[0029] The JZ-NSMD001 organic solution that embodiment makes is carried out toxicity test as follows:
[0030] (1) Acute oral toxicity test
[0031] The test was carried out according to GB / T 21603-2008 Chemical Acute Oral Toxicity Test Method. SD rats were used in the experiment. Before gavage, the experimental animals were fasted overnight. In the experiment, 20 animals (half male and half male) were infected with 5000mg / kg bw dose. After administration, observe and record the signs of poisoning and the death rate in the two-week observation period of the rats, and conduct autopsy observations.
[0032] (2) Acute inh...
Embodiment 1
[0047] Put 82mL of trifluorotrichloroethane, 1mL of 2,2,4,6,6-pentamethylheptane, 1mL of 2,2,7,7-tetramethyloctane, 1mL of n-dodecane and 15mL of ethanol into In a beaker, use a glass rod to stir and mix to prepare an organic solution of JZ-NSMD001.
[0048]The JZ-NSMD001 organic solution that the present embodiment makes is carried out toxicity test as follows:
[0049] (1) Acute oral toxicity test
[0050] Observe and record the rat's poisoning sign and the mortality rate (see Table 1 and Table 2) within the two-week observation period. During the test period, no animal death and poisoning sign were seen; no abnormality was observed in the autopsy. According to the test results, the acute oral toxicity LD of the test sample 50 Value >5000mg / kg (rat).
[0051] Table 1 Cumulative number of animal deaths
[0052]
[0053] Table 2 Observation of signs of poisoning
[0054]
[0055] NA = no abnormality seen
[0056] (2) Acute inhalation toxicity test
[0057] Observe...
Embodiment 2
[0075] Put 75mL of trifluorotrichloroethane, 3mL of 2,2,4,6,6-pentamethylheptane, 1mL of 2,2,7,7-tetramethyloctane, 1mL of n-dodecane and 20mL of ethanol In a beaker, use a glass rod to stir and mix to prepare an organic solution of JZ-NSMD001.
[0076] The JZ-NSMD001 organic solution that the present embodiment makes is carried out toxicity test as follows:
[0077] (1) Acute oral toxicity test
[0078] Observe and record the signs of poisoning and the mortality of the rats during the two-week observation period. During the test period, no animal death and signs of poisoning were observed; no abnormality was observed in the autopsy. According to the test results, the acute oral toxicity LD of the test sample 50 Value >5000mg / kg (rat).
[0079] (2) Acute inhalation toxicity test
[0080] Observe and record the signs of poisoning and the mortality of the rats during the two-week observation period. During the test period, no animal death and signs of poisoning were observed...
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