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Mark-free tumor marker detection system and method based on micro-nano structure optical chip

A technology for tumor markers and detection systems, which is applied in the field of label-free tumor marker detection systems and the preparation of micro-nano structured light chips. And other issues

Pending Publication Date: 2022-04-19
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The embodiment of the present invention provides a label-free tumor marker detection system based on a micro-nano structured light chip, which aims to solve the problem of high cost and bulky detection instruments in the prior art, which cannot meet the requirements of low-cost and portable in vitro diagnostics, and are difficult to detect. Problems in mass production and popularization of point-of-care diagnostic markets such as community hospitals

Method used

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  • Mark-free tumor marker detection system and method based on micro-nano structure optical chip
  • Mark-free tumor marker detection system and method based on micro-nano structure optical chip
  • Mark-free tumor marker detection system and method based on micro-nano structure optical chip

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Embodiment 1

[0043] see figure 1 and figure 2 , the embodiment of the present invention provides a label-free tumor marker detection system based on a micro-nano structured light chip, characterized in that the detection system includes: a hardware detection system 100, a background service system 200 and a remote terminal system 300;

[0044] The hardware detection system 100 is used to detect the valley data of the reflection valley on the surface of the micro-nano structure chip 106, and calculate the offset data of the reflection valley on the surface of the micro-nano structure chip 106 according to the valley data;

[0045] The background server 200 includes a cloud server 201 that transmits the offset data, a database 202 that stores the offset data, and an Internet platform 203 that distributes data to users;

[0046] The remote terminal system 300 is configured to present visual detection results to the user.

[0047] In the embodiment of the present invention, the hardware det...

Embodiment 2

[0053] see image 3 , in the embodiment of the present invention, the micro-nano structure chip 106 includes: a sample introduction area 1061, a nano-structure detection area 1062, a surface plasmon detection chip 1063, a microfluidic channel 1064, a waste liquid pool 1065, a surface plasmon The meta-detection chip 1063 is set in the nanostructure detection area 1062; wherein, the sample injection area 1061 is used to inject the serum to be tested; the nanostructure detection area 1062 is used to detect the serum to be tested on the surface plasmon detection chip 1063 to obtain the surface The trough data of the reflection trough on the surface of the plasmon detection chip 1063; the microfluidic channel 1064 is used to connect the sample injection area 1061, the nanostructure detection area 1062, and the waste liquid pool 1065, so that the serum to be tested is injected from the sample injection area 1061 and flows through the After the nanostructure detection area 1062 is de...

Embodiment 3

[0057] The embodiment of the present invention also provides a method for preparing the above-mentioned micro-nano structure chip 106, the preparation method includes: separately preparing the surface plasmon detection chip 1063 and the microfluidic channel 1064; wherein, the above-mentioned preparation of the surface plasmon detection The steps of chip 1063 specifically include:

[0058] S1: Transfer the micro-nano structure onto impact-resistant polystyrene (IPS, Impact-resistant-polystyrene) by hot embossing;

[0059] S2: UV imprinting is used to transfer the micro-nano structure on the impact-resistant polystyrene to the silicon substrate spin-coated with photoresist to form an imprinting glue;

[0060] S3: using an electron beam evaporation apparatus to sequentially evaporate chromium and gold on the surface of the embossing glue to make a surface plasmon detection chip 1063 .

[0061] As a preferred embodiment of the present invention, the thickness of the evaporated ch...

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Abstract

The invention is applicable to the technical field of biomedical detection, and provides a label-free tumor marker detection system based on a micro-nano structure optical chip and a preparation method of the micro-nano structure optical chip, the detection system comprises a hardware detection system, a background service system and a remote terminal system; the hardware detection system is used for detecting trough data of reflection valleys on the surface of the micro-nano structure chip and calculating offset data of the reflection valleys on the surface of the micro-nano structure chip according to the trough data; the background server comprises a cloud server for transmitting offset data, a database for storing the offset data and an internet platform for distributing data to users; and the remote terminal system is used for presenting the visual detection result to a user. The label-free tumor marker detection system based on the micro-nano structure optical chip is low in cost and better in portability, and early cancer detection is more accurate, intelligent and rapid.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and in particular relates to a label-free tumor marker detection system based on a micro-nano structured light chip and a preparation method of the micro-nano structured light chip. Background technique [0002] The World Health Organization's 2017 cancer statistics report pointed out that early screening can reduce cancer incidence and mortality. At present, among the patients diagnosed for the first time in hospitals all over the country, only about 10% suffer from early cancer, and more than 90% of patients have missed the key opportunity to overcome cancer. Therefore, it is urgent to improve the early detection rate of cancer. [0003] Now the Siemens chemiluminescence instrument is generally used in the market, and its price is more than 2 million yuan. Currently, only the top three hospitals in China can buy and use it, and these detection instruments are expensive and bulky, ...

Claims

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Application Information

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IPC IPC(8): G01N21/31G01N21/01
CPCG01N21/31G01N21/01
Inventor 朱锦锋申家情李法君熊健凯王正瑛谢奕浓郭子超
Owner XIAMEN UNIV
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