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Composition for constructing urolithiasis cat disease model

A disease model and composition technology, which is applied in compound screening/testing, preparations for in vivo experiments, and pharmaceutical formulations, can solve problems such as the absence of suitable compositions for constructing urolithiasis cat disease models, and achieve prevention and urolithiasis Formation, less damage, and the effect of delaying the formation of stones

Pending Publication Date: 2022-04-22
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a composition for constructing a cat disease model of urolithiasis, so as to solve the problem that there is no composition suitable for constructing a cat disease model of urolithiasis at present

Method used

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  • Composition for constructing urolithiasis cat disease model
  • Composition for constructing urolithiasis cat disease model
  • Composition for constructing urolithiasis cat disease model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Comprising the following raw materials in parts by volume ratio:

[0029] Appease 60 parts,

[0030] 15 parts of stone attractant,

[0031] 15 parts of stone-forming agent,

[0032] 35 parts of nutritional supplements;

[0033] The appeasement of the present invention includes the following raw materials in volume percentage: 3.3% of cat pheromone FF3 analog, 96.7% of tripropylene glycol methyl ether;

[0034] The stone-attracting agent of the present invention is selected from 1% ethylene glycol solution;

[0035] The 1% ethylene glycol solution of the present invention is obtained by adding 1ml ethylene glycol into 100ml 0.9% sodium chloride solution until fully dissolved;

[0036] The stone forming agent of the present invention is selected from 1% glyoxylic acid solution;

[0037] The 1% glyoxylic acid solution of the present invention is obtained by adding 2ml of 50% glyoxylic acid into 100ml of 0.9% sodium chloride solution until completely dissolved;

[003...

Embodiment 2

[0040] Comprising the following raw materials in parts by volume ratio:

[0041] Appease 40 parts,

[0042] Stone attractant 5 parts,

[0043] 5 parts of stone-forming agent,

[0044] 25 parts of nutritional supplements;

[0045] The appeasement of the present invention includes the following raw materials in volume percentage: 3.3% of cat pheromone FF3 analog, 96.7% of tripropylene glycol methyl ether;

[0046] The stone-attracting agent of the present invention is selected from 1% ethylene glycol solution;

[0047] The 1% ethylene glycol solution of the present invention is obtained by adding 1ml ethylene glycol into 100ml 0.9% sodium chloride solution until fully dissolved;

[0048] The stone forming agent of the present invention is selected from 1% glyoxylic acid solution;

[0049] The 1% glyoxylic acid solution of the present invention is obtained by adding 2ml of 50% glyoxylic acid into 100ml of 0.9% sodium chloride solution until completely dissolved;

[0050] Th...

Embodiment 3

[0052] Comprising the following raw materials in parts by volume ratio:

[0053] Appease 50 parts,

[0054] 10 parts of stone attractant,

[0055] 10 parts of stone-forming agent,

[0056] 30 parts of nutritional supplements;

[0057] The appeasement of the present invention includes the following raw materials in volume percentage: 3.3% of cat pheromone FF3 analog, 96.7% of tripropylene glycol methyl ether;

[0058] The stone-attracting agent of the present invention is selected from 1% ethylene glycol solution;

[0059] The 1% ethylene glycol solution of the present invention is obtained by adding 1ml ethylene glycol into 100ml 0.9% sodium chloride solution until fully dissolved;

[0060] The stone forming agent of the present invention is selected from 1% glyoxylic acid solution;

[0061] The 1% glyoxylic acid solution of the present invention is obtained by adding 2ml of 50% glyoxylic acid into 100ml of 0.9% sodium chloride solution until completely dissolved;

[0062]...

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Abstract

The invention relates to a composition for constructing a urolithiasis cat disease model, and belongs to the technical field of animal disease model construction. Comprising the following raw materials in parts by volume: 40-60 parts of a pacifying agent, 5-15 parts of a stone inducing agent, 5-15 parts of a stone making agent and 25-35 parts of a nutritional agent. The method has the advantages that damage to an experimental animal body is small, self-recovery can be achieved in the later period, an ideal disease model is provided for exploring an effective treatment method, the method is suitable for being used in research of owl urolithiasis, and a model basis is provided for pathogenesis research of the disease and screening of treatment drugs. According to the animal model of the cat urolithiasis disease, which is obtained by the construction method disclosed by the invention, not only can the formation process of urinary calculi be deeply understood, but also the screening of anti-calculi Chinese and western medicines can be helped. The method has important significance in the aspects of discussing the pathogenesis of the urinary calculus, preventing and delaying the formation of the calculus, searching medicines for preventing and treating the urinary calculus and the like.

Description

technical field [0001] The invention relates to the technical field of constructing animal disease models, in particular to a composition for constructing urolithiasis feline disease models. Background technique [0002] Feline urolithiasis is a syndrome with frequent urination, oliguria, hematuria and even anuria as the main clinical manifestations caused by urinary tract stones and microlithiasis stimulating the urinary tract mucosa, resulting in urinary tract obstruction. In general, it is a common disease of cats, and it is more common in urethral calculi and bladder calculi. Urolithiasis refers to the precipitation of salt crystals in urine, which gradually increase in size and become condensed matter formed in the kidney or bladder by the salt in the form of particles, which stimulates and damages the urinary tract mucosa and causes urethral obstruction. systemic disease. This disease occurs frequently in cats, and most of the urinary crystals and urinary calculi are...

Claims

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Application Information

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IPC IPC(8): A01K67/02A61K49/00
CPCA01K67/02A61K49/0008A01K2227/10A01K2207/20A01K2207/25A01K2267/03
Inventor 鲁泽宇车旗赢靳朝
Owner JILIN UNIV
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