Cefalonium breast injectant as well as preparation method and application thereof

A technology of breast injection and cefuroxime, which is applied in the field of cefuroxime breast injection and its preparation, can solve the problems that the drug concentration cannot be maintained until the perinatal period and the long milk abandonment period, and achieves the problem of milk abandonment period, The effect of short milk abandonment period and high drug content

Active Publication Date: 2022-04-29
SHANDONG LUKANG SHELILE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the case of traditional breast injections with a long dry milk period, the drug concentration cannot be maintained until the perinatal period, or can be maintained until the perinatal period, but the milk abandonment period is long

Method used

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  • Cefalonium breast injectant as well as preparation method and application thereof
  • Cefalonium breast injectant as well as preparation method and application thereof
  • Cefalonium breast injectant as well as preparation method and application thereof

Examples

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preparation example Construction

[0040] The present invention also provides the preparation method of described ceftaroning breast injection, comprises the steps:

[0041] Mix the emulsifier and the oily solvent, and homogenize the obtained mixture for the first time to prepare a homogeneous liquid;

[0042]Mix the homogenized liquid and cefuroxime, and homogenize the obtained mixture for the second time to prepare the cefuroxime breast injection.

[0043] In one specific example, the conditions for the first homogenization include: the pressure is 450bar-550bar. Specifically, the pressure of the first homogenization includes but is not limited to: 450 bar, 460 bar, 470 bar, 480 bar, 490 bar, 500 bar, 510 bar, 520 bar, 530 bar, 540 bar, 550 bar.

[0044] In one specific example, the number of times of the first homogenization is 1.

[0045] In one specific example, the conditions for the second homogenization include: a pressure of 950 bar to 1050 bar. Specifically, the pressure of the second homogenizatio...

Embodiment 1

[0050] Present embodiment is a kind of ceftaroning breast injection, and the composition of every 3g is composed of:

[0051]

[0052] The preparation method of above-mentioned ceftaroning breast injection is as follows:

[0053] (1) Add Span 80, lecithin, and Tween 20 to medium-chain fatty acid glycerides, and homogenize once with a high-pressure homogenizer at a pressure of 500 bar to obtain Liquid A;

[0054] (2) Put the main drug cefuroxime into the liquid A, homogenize twice at low temperature with a high-pressure homogenizer, and the pressure is 1000 bar to obtain the cefuroxime breast injection.

Embodiment 2

[0056] Present embodiment is a kind of ceftaroning breast injection, and the composition of every 3g is composed of:

[0057]

[0058] The preparation method of above-mentioned ceftaroning breast injection is as follows:

[0059] (1) Add Span 80, lecithin, and Tween 20 into ethyl oleate, homogenize once with a high-pressure homogenizer at a pressure of 500 bar, and obtain Liquid A;

[0060] (2) Put the main drug cefuroxime into the liquid A, homogenize twice at low temperature with a high-pressure homogenizer, and the pressure is 1000 bar to obtain the cefuroxime breast injection.

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PUM

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Abstract

The invention relates to a cefalonium breast injectant as well as a preparation method and application thereof. According to 3 g of the cefalonium breast injectant, the cefalonium breast injectant is prepared from 120 mg to 360 mg of cefalonium, 120 mg to 360 mg of an emulsifying agent and an oily solvent, wherein the emulsifier is a mixture of tween, span and lecithin in a mass ratio of (3-5): (2-4): 1. The cefalonium breast injectant is good in dispersity in mammary glands, not prone to sedimentation in the long-term storage process and good in stability. Meanwhile, the traditional Chinese medicine has the advantages of good curative effect and short milk discarding period.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a ceftaroning breast injection and a preparation method and application thereof. Background technique [0002] Cow mastitis is a common and frequently-occurring disease of dairy cows. It is difficult to prevent and treat, and the cost of treatment is high. The dry period is the period when cows stop lactating before giving birth. It usually lasts for about 2 months. It is an important period for mammary gland recovery and the best period for the prevention and treatment of mastitis in dairy cows. The main purpose of dry period treatment is to reduce the level of existing breast infection and prevent new infection. To achieve these two goals, it is necessary to use broad-spectrum, long-acting antibacterial drugs for dry period treatment. [0003] Cefuronine is the first generation of semi-synthetic cephalosporin antibiotics. It has a strong killing effect on S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/00A61K31/546A61K47/26A61K47/22A61K47/24A61K47/14A61P15/14A61P31/04
CPCA61K9/0041A61K9/0019A61K9/107A61K31/546A61K47/26A61K47/22A61K47/24A61K47/14A61P15/14A61P31/04
Inventor 吉利伟董玲玲武茂成郭晓梅赵春蕊张素卿李彤李荣孙茹郭强
Owner SHANDONG LUKANG SHELILE PHARMA
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