Detection method for determining 12 elements in radix astragali through dry ashing-lithium metaborate alkali fusion

Abstract

The invention discloses a detection method for determining 12 elements in radix astragali through dry ashing-lithium metaborate alkali fusion, which comprises the following steps: gradually ashing a traditional Chinese medicinal material radix astragali sample in a muffle furnace, adding lithium metaborate for alkali fusion, carrying out ultrasonic extraction with a dilute HCl solution, carrying out volume metering and shaking up, carrying out inductively coupled plasma emission spectrometer (ICP-OES) test, and determining the content of 12 elements in radix astragali through dry ashing-lithium metaborate alkali fusion. Analyzing the spectral line intensity response value of each element, and quantifying each element of the sample through the standard curve. According to the method, a step-by-step ashing-lithium metaborate alkali fusion-inductively coupled plasma emission spectrometry (ICP-OES) method for determining 12 elements such as silicon, aluminum and the like in astragalus membranaceus is established, the test quality technical indexes can meet the actual sample analysis requirement, the precision of each element is within 10%, the requirements on the analysis method in the General Rule 9101 of Pharmacopoeia of the People's Republic of China are met, and the method has the advantages of simple operation, high accuracy and high accuracy. And a scientific basis is provided for safe production of astragalus membranaceus.

Description

technical field [0001] The invention relates to the technical field of determination of 12 elements in Radix Astragali, more specifically, a dry ashing-lithium metaborate alkali fusion detection method for determining 12 elements in Radix Astragali. Background technique [0002] Chinese herbal medicines are the raw materials of traditional Chinese medicine decoction pieces and prescription preparations, and their quality is directly related to the safety and efficacy of clinical medication, so the quality control of Chinese herbal medicines is particularly important. At the same time, with the application of Chinese medicinal materials in the world, the quality control of Chinese medicinal materials is the core issue to ensure the "safety, stability, effectiveness and controllability" of traditional Chinese medicine, and to realize the modernization, industrialization and internationalization of traditional Chinese medicine. For Chinese herbal medicines from different origin...

AI Technical Summary

Problems solved by technology

The main reference standards for the detection of Chinese medicinal materials are general rules 9304, 0411, and 0412 of the Pharmacopoeia of the People's Republic of China. The microwave digestion, pressure tank digestion, wet digestion, and acid dissolution after dry digestion in the method are not suitable for Si and Al. Incomplete dissolution leads to low result values; direct alkali fusion can easily lead to high blank values, and the high salt content of the solution affects the detection limit. It is difficult to solve the pretreatment problem of simultaneous determination of Si, Al and other elements

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