Pharmaceutical composition for treating child sexual precocity and application thereof

A composition and medicine technology, applied in the field of traditional Chinese medicine, can solve the problems of decreased sex hormone level, expensive medicine, cannot prevent short stature, etc., and achieve the effects of short course of treatment, thorough curative effect and obvious effect.

Pending Publication Date: 2022-05-13
江西省儿童医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the curative effect of GnRHa is certain, but generally it should be treated continuously for several months to several years, until it is close to the age of puberty, the drug price is expensive, and it will bring a great economic burden to the families of most children; progesterone hormone therapy is also used , to reduce the level of sex hormones and the disappearance of sexual characteristics, but it is ineffective for delaying skeletal maturation and controlling bone growth acceleration, so it cannot prevent short stature, and it is rarely used alone in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Recipe composition:

[0052] Chinese yam medicine 15 grams, Poria cocos 15 grams, Anemarrhena 10 grams, Scrophulariae 10 grams, Radix Paeoniae Rubra 10 grams, Rehmannia glutinosa 10 grams, Alisma alisma salt 10 grams, Prunella vulgaris 10 grams, Coix seed 20 grams, Cornus officinalis 20 grams.

[0053] Preparation method: weigh the medicinal materials according to the above formula, add 300ml of water, decoct twice, and combine the obtained decoctions.

Embodiment 2

[0054] Embodiment 2: clinical diagnosis and treatment case

[0055] 1. Cases

[0056] All cases are outpatients of Jiangxi Provincial Children's Hospital in June 2019, as follows:

[0057] Date of visit / name / ID number / date of visit / diagnosis result / name of medicine

[0058] 2019.6.1 / Xiong Moumou / 10622751 / breast hypertrophy / PT No. 2

[0059] 2019.6.1 / Wang Moumou / 8600142298 / precocious puberty / PT No. 2

[0060] 2019.6.1 / Liu Moumou / 101772253 / Precocious Puberty / PT No. 2

[0061] 2019.6.1 / Rao XX / 8600136229 / Premature Puberty / PT No. 2

[0062] 2019.6.1 / Yu Moumou / 8600114745 / Premature Puberty / PT No. 2

[0063] 2019.6.1 / Tang Moumou / 8600106734 / Breast hypertrophy / PT No. 2

[0064] 2019.6.1 / Ding Mou / 101329771 / Premature Puberty / PT No. 2

[0065] 2019.6.1 / Tao Moumou / 8600150484 / Precocious Puberty / PT No. 2

[0066] 2019.6.1 / Cheng Moumou / 100598674 / Precocious Puberty / PT No. 2

[0067] 2019.6.1 / Zhang Moumou / 11205309 / Breast hypertrophy / PT No. 2

[0068] 2019.6.1 / Du Moumou / 8600157915 / breas...

Embodiment 3

[0162] Embodiment 3 No. 8600331657 patient diagnosis and treatment case

[0163] Date: 2019 / 9 / 19

[0164] The child recently found that the left breast developed without tenderness and vaginal bleeding. He denied taking hormones or contraceptives by mistake.

[0165] Physical examination: height 103.8cm, clear mind, good spirits, no special face, no skin rash, no special cardiopulmonary auscultation, soft abdomen. Short stature. Specialist examination: no acne, left breast B2 stage, breast nucleus 0.8 × 0.8cm 2 .

[0166] It was diagnosed as precocious puberty and growth retardation.

[0167] Adopt the obtained decoction of embodiment 1 (being No. PT2), each warm service once in the morning and evening, 1 month is a course for the treatment of, take 2 courses for the treatment of continuously.

[0168] Date: 2019 / 10 / 5

[0169] Reexamination after breast development treatment in children.

[0170] The child's breast enlargement improved after treatment.

[0171] Physica...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating child sexual precocious puberty and application of the pharmaceutical composition. The pharmaceutical composition comprises the following traditional Chinese medicinal raw material components in parts by weight: 10-20 parts of common yam rhizome, 10-20 parts of poria cocos, 5-15 parts of salted rhizoma anemarrhenae, 5-15 parts of radix scrophulariae, 5-15 parts of radix paeoniae rubra, 5-15 parts of radix rehmanniae recen, 5-15 parts of salted rhizoma alismatis, 5-15 parts of selfheal, 15-25 parts of semen coicis and 15-25 parts of dogwood. The pharmaceutical composition provided by the invention has a very good curative effect on children's sexual precocity, especially children's sexual precocity with kidney yin deficiency and spleen deficiency syndromes, especially has an obvious curative effect on children's simple breast development, and has the advantages of good curative effect, short course of treatment, thorough curative effect, no side effect and the like.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating precocious puberty in children, especially precocious puberty in children with syndrome of kidney yin deficiency and spleen deficiency, and its application. Background technique [0002] With the improvement of living standard and educational level and the change of social environment, children's precocious puberty is increasing year by year. Because of its serious impact on children's height and psychological state, it has been paid more and more attention by the society. Child Precocious Puberty (CPP) is a common endocrine disease in children. It is an abnormal phenomenon of growth and development. An endocrine disorder in which sexual characteristics or menarche occurs before the age of 10 in girls. Precocious puberty can be divided into two types, namely true precocious puberty and false precocious puberty. The ...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P5/24
CPCA61K36/8945A61K36/076A61K36/8964A61K36/808A61K36/71A61K36/65A61K36/804A61K36/884A61K36/536A61K36/8994A61K36/40A61P5/24A61K2300/00
Inventor 陶强杨玉
Owner 江西省儿童医院
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