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Application of ginsenoside Rc in preparation of medicine for treating alcoholic fatty liver

A technology of alcoholic fatty liver and ginsenosides is applied in the field of medicine to achieve the effects of inhibiting lipid accumulation, inhibiting liver damage and inhibiting inflammatory response

Pending Publication Date: 2022-05-27
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As the main active ingredient of ginseng, ginsenoside Rc has significant curative effects in anti-inflammation and anti-oxidation, and the prior art discloses the application of ginsenoside Rc in the treatment of diseases related to liver fibrosis. However, liver fibrosis is caused by various Abnormal hyperplasia of connective tissue in the liver caused by two pathogenic factors. Alcoholic fatty liver is liver fatty infiltration caused by long-term heavy drinking. It can be seen that the pathogenesis of the two is essentially different, and it can be used as a drug for treating liver fibrosis-related diseases Does not necessarily cure alcoholic fatty liver

Method used

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  • Application of ginsenoside Rc in preparation of medicine for treating alcoholic fatty liver
  • Application of ginsenoside Rc in preparation of medicine for treating alcoholic fatty liver
  • Application of ginsenoside Rc in preparation of medicine for treating alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 The effect of ginsenoside Rc on alcoholic fatty liver

[0029] 1. Ginsenoside Rc can effectively inhibit the apoptosis of liver cells in alcoholic fatty liver

[0030] (1) Experimental method

[0031] Primary hepatocytes were isolated from C57BL / 6J mice and divided into six groups: blank group (PBS+DMSO group) added 1 μl / ml DMSO in 1640 complete medium containing 100mM PBS for modeling; control group (EtOH+DMSO group) Group) 1 μl / ml DMSO was added to 1640 complete medium containing 100 mM alcohol for modeling; experimental group A (EtOH+Rc (12.5 μM) group) was added 1 μl / ml 12.5 mM 1640 complete medium containing 100 mM alcohol Ginsenoside Rc was used for modeling; experimental group B (EtOH+Rc (25 μM) group) was added 1 μl / ml 25 mM ginsenoside Rc to 1640 complete medium containing 100 mM alcohol for modeling; experimental group C (EtOH+Rc (50 μM) Group) Add 1 μl / ml 50 mM ginsenoside Rc to 1640 complete medium containing 100 mM alcohol for modeling; experime...

Embodiment 2

[0046] Example 2 The effect of ginsenoside Rc on acute alcoholic fatty liver

[0047] 1. Experimental method

[0048] Forty-two C57BL / 6J mice were divided into six groups: each mouse in the blank group (Ctr+Saline group) was intraperitoneally injected with ten times the volume of normal saline; each mouse in the control group A (Ctr+Rc(H) group) Intraperitoneal injection of 2 mg / ml ginsenoside Rc at a volume ten times of body weight; control group B (EtOH+Saline group) by intraperitoneal injection of physiological saline ten times the volume of body weight; experimental group A (EtOH+Rc(L) group) Each mouse was intraperitoneally injected with 0.5 mg / ml ginsenoside Rc at a volume ten times its body weight; experimental group B (EtOH+Rc(M) group) was intraperitoneally injected with 1 mg / ml ginsenoside Rc at a volume ten times its body weight. ; Experimental group C (EtOH+Rc(H) group) was intraperitoneally injected with 2 mg / ml ginsenoside Rc at a volume ten times its body weigh...

Embodiment 3

[0052] Example 3 The effect of ginsenoside Rc on chronic alcoholic fatty liver

[0053] 1. Experimental method

[0054] 42 C57BL / 6J mice were divided into six groups: blank group (Ctr+Saline group), control group A (Ctr+Rc(H) group), control group B (EtOH+Saline group), experimental group A (EtOH+ Rc(L) group), experimental group B (EtOH+Rc(M) group), experimental group C (EtOH+Rc(H) group).

[0055] In order to construct a disease model of chronic alcoholic fatty liver disease, firstly, six groups of mice were adaptively fed control liquid feed freely for 1 day; vol / vol) ethanol liquid feed, the blank group and control group A continued to be fed with control liquid feed; on the 6th to 9th day, mice in control group B and experimental groups A to C were fed with 5% (vol / vol) ethanol. Liquid feed, blank group and control group A continued to feed control liquid feed; from 10 to 16 days, mice in control group A and experimental groups A to C were injected with 10ul / g ginsenos...

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Abstract

The invention provides application of ginsenoside Rc in preparation of a medicine for treating alcoholic fatty liver. Researches show that ginsenoside Rc can effectively inhibit liver injury, lipid accumulation, oxidative stress reaction and inflammatory reaction, so that acute / chronic alcoholic fatty liver is effectively treated, and a new material source is provided for the medicine for treating the alcoholic fatty liver.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to the application of ginsenoside Rc in the preparation of a medicine for treating alcoholic fatty liver. Background technique [0002] With the development of today's society, drinking has become a very common behavior in interpersonal entertainment. However, long-term heavy drinking may lead to abnormal mitochondrial function in liver cells, resulting in excessive accumulation of reactive oxygen species, triggering oxidative stress, and may also lead to in vivo Changes in the activity of biological enzymes, causing liver damage and steatosis of liver cells, etc., if not treated in time, may develop into alcoholic fatty liver disease (AFLD), the clinical symptoms are non-specific, may be asymptomatic, or There are right upper quadrant pain, loss of appetite, fatigue, weight loss and so on. [0003] At present, the clinical treatment of alcoholic fatty liver is us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K36/258A61P1/16
CPCA61K31/704A61K36/258A61P1/16
Inventor 高永唐凯佳潘治森刘昌辉
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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