Application of model constructed based on PCD related gene combination in preparation of product for predicting prognosis of colonic adenocarcinoma

A colon adenocarcinoma and gene combination technology, applied in the field of biomedicine, can solve the problem of unclear effect of cancer immunotherapy, achieve optimal immune response and tolerance, avoid overtreatment and delay the patient's condition.

Pending Publication Date: 2022-05-27
郑州源创基因科技有限公司 +1
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Problems solved by technology

Modulation of PCD mechanisms in TME immune cells can stimulate tumor progression and immune evasion; despite recent progress in multi-omics approaches and identification of new prognostic biomarkers for COAD, however, considering that PCD pathways are interconnected and new PCD types ( The role of ferroptosis and pyrop...

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  • Application of model constructed based on PCD related gene combination in preparation of product for predicting prognosis of colonic adenocarcinoma
  • Application of model constructed based on PCD related gene combination in preparation of product for predicting prognosis of colonic adenocarcinoma
  • Application of model constructed based on PCD related gene combination in preparation of product for predicting prognosis of colonic adenocarcinoma

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Embodiment 1

[0028] Screening of PCD-related genes for the construction of a model for COAD prognostic analysis.

[0029] (1) Obtaining patient information: RNA-seq data and clinical characteristics of COAD patients were obtained from The Cancer Genome Atlas (TCGA) database (https: / / portal.gdc.cancer.gov / reposito57Sry). After data screening and filtering, COAD samples and normal samples were selected from the TCGA-COAD cohort. Four external validation datasets GSE17536 (n=177), GSE17537 (n=55), GSE39582 (n=479) and GSE29623 (n=65) were used for external validation. As shown in Table S1.

[0030] (2) Screening prognosis-related PCD-related genes as prognostic biomarkers for constructing a prognostic model and validating the prognostic model: use

[0031] http: / / www.zhounan.org / ferrdb / , http: / / www.autophagy.lu / index.html http: / / www.gsea-msigdb.org / gsea / index.jsp, https: / / www.kegg .jp / entry / hsa04217 and other databases screened and extracted ferroptosis, autophagy, pyroptosis, apoptosis an...

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Abstract

The invention discloses application of a model constructed based on a PCD related gene combination in preparation of a product for predicting prognosis of colonic adenocarcinoma. 14 PCD key genes differentially expressed in colorectal cancer, including (SPTBN2, DNAJC2, DRD4, SH3GL3, FOXS1, GSTM1, ISSYNA1, NOL3, GPR27, PPARGC1A, RAB36, SEZ6L2, SERPINE1 and TNNT1), are adopted as detection targets to construct a prognosis model PCDSig, the model has good clinical prognosis prediction ability for one year, two years and three years, the model can better distinguish high-risk people from low-risk people, and high-risk and low-risk patients have the characteristics of immune infiltration, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency and the like. The response of immunotherapy is different from the aspects of drug target gene expression and chemotherapy drug sensitivity, target benefit people can be screened through the model, clinical precise and personalized treatment is effectively guided, and excessive treatment and patient condition delay are avoided. On the basis of the model, a column diagram for predicting the survival probabilities of the patient in one year, three years and five years is developed, so that the model is visualized, and conditions are provided for clinicians to judge the prognosis of the COAD patient.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of a model constructed based on PCD-related gene combination in preparing a product for predicting the prognosis of colon adenocarcinoma. Background technique [0002] Colon adenocarcinoma (COAD), one of the most common malignant tumors worldwide, involves multiple immune mechanisms and is highly heterogeneous. Despite recent advances in diagnostic and therapeutic strategies, increased drug resistance in patients with colon adenocarcinoma has limited its therapeutic efficacy, resulting in a still poor 5-year survival rate for patients with colon adenocarcinoma. [0003] Abnormalities in programmed cell death (PCD) pathways of apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis have been implicated in the pathogenesis of various cancers, including COAD, and understanding the underlying molecular mechanisms can lead to Help develop a personalized tre...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11G16B5/00G16B25/10G16B40/00
CPCC12Q1/6886G16B5/00G16B25/10G16B40/00C12Q2600/118C12Q2600/158C12Q2600/106
Inventor 徐茜赵辉郭玉刚高萧芳孙宪凯
Owner 郑州源创基因科技有限公司
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