Application of model constructed based on PCD related gene combination in preparation of product for predicting prognosis of colonic adenocarcinoma

Abstract

The invention discloses application of a model constructed based on a PCD related gene combination in preparation of a product for predicting prognosis of colonic adenocarcinoma. 14 PCD key genes differentially expressed in colorectal cancer, including (SPTBN2, DNAJC2, DRD4, SH3GL3, FOXS1, GSTM1, ISSYNA1, NOL3, GPR27, PPARGC1A, RAB36, SEZ6L2, SERPINE1 and TNNT1), are adopted as detection targets to construct a prognosis model PCDSig, the model has good clinical prognosis prediction ability for one year, two years and three years, the model can better distinguish high-risk people from low-risk people, and high-risk and low-risk patients have the characteristics of immune infiltration, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency, immune deficiency and the like. The response of immunotherapy is different from the aspects of drug target gene expression and chemotherapy drug sensitivity, target benefit people can be screened through the model, clinical precise and personalized treatment is effectively guided, and excessive treatment and patient condition delay are avoided. On the basis of the model, a column diagram for predicting the survival probabilities of the patient in one year, three years and five years is developed, so that the model is visualized, and conditions are provided for clinicians to judge the prognosis of the COAD patient.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of a model constructed based on PCD-related gene combination in preparing a product for predicting the prognosis of colon adenocarcinoma. Background technique [0002] Colon adenocarcinoma (COAD), one of the most common malignant tumors worldwide, involves multiple immune mechanisms and is highly heterogeneous. Despite recent advances in diagnostic and therapeutic strategies, increased drug resistance in patients with colon adenocarcinoma has limited its therapeutic efficacy, resulting in a still poor 5-year survival rate for patients with colon adenocarcinoma. [0003] Abnormalities in programmed cell death (PCD) pathways of apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis have been implicated in the pathogenesis of various cancers, including COAD, and understanding the underlying molecular mechanisms can lead to Help develop a personalized tre...

AI Technical Summary

Problems solved by technology

Modulation of PCD mechanisms in TME immune cells can stimulate tumor progression and immune evasion; despite recent progress in multi-omics approaches and identification of new prognostic biomarkers for COAD, however, considering that PCD pathways are interconnected and new PCD types ( The role of ferroptosis and pyroptosis in the tumor microenvironment and its impact on cancer immunotherapy are still unclear, and there are very few studies on the combination of immune cell infiltration and immune pathways

There is currently no PCD-associated differentially expressed gene (PCDDEG) prognostic model for systematic assessment of COAD prognosis

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