Dissoluble microneedle containing active microalgae, microneedle patch, preparation method and application
A technology of microneedle patch and microalgae, applied in the field of microneedle patch, preparation, and dissolvable microneedle, can solve the problems of poor patient compliance, insufficient delivery depth, affecting drug absorption, etc., and achieve high biocompatibility, good adaptability
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[0033] In the third aspect, the embodiment of the present invention also provides a method for preparing a dissolving microneedle patch based on active microalgae, which includes: mixing active microalgae with photosynthesis, a water-soluble polymer material and sterile water, pouring In the microwell array mold, centrifuge to remove air bubbles, then add the polymer material for preparing the backing, secondly centrifuge and dry to prepare a dissolvable microneedle patch.
[0034] In an optional embodiment, the preparation method of the dissolvable microneedle patch comprises the following steps: 5 -10 8 Each milliliter of active microalgae is mixed with a water-soluble polymer solution with a concentration of 30%-50%, and then the final mixed solution is poured into a polydimethylsiloxane microwell array mold and centrifuged at a speed of 3000-5000rpm for 30 -60 minutes;
[0035] Add the polymer solution with a concentration of 10%-70% to prepare the backing part into the ...
Embodiment 1
[0061] This example provides a method for preparing a dissolving microneedle patch based on active microalgae. In this example, the microalgae is Chlorella, purchased from Shanghai Guangyu Biotechnology Co., Ltd., hyaluronic acid, polyvinylpyrrolidone and The polyvinyl alcohol was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd., and the polydimethylsiloxane microwell array mold was purchased from Taizhou Microchip Pharmaceutical Technology Co., Ltd.
[0062] Prepared hyaluronic acid solution (Mw 20kDa, 30% (w / v)), and polyvinylpyrrolidone (Mw 30kDa, 30% (w / v)) and polyvinyl alcohol mixed solution (Mw 30kDa, 30% (w / v), 1:1 (w / w)) and fully exhaust the air bubbles by ultrasonic dissolution.
[0063] Set the concentration to 10 7 Each milliliter of 3 milliliters of microalgae mother liquor was centrifuged to remove the medium, then 1 milliliter of hyaluronic acid solution was added, the needle mixture was poured into the polydimethylsiloxane microwell array mol...
Embodiment 2
[0067] This example provides a method for preparing a dissolving microneedle patch based on active microalgae. In this example, the microalgae is Spirulina, purchased from Shanghai Guangyu Biotechnology Co., Ltd., chitosan, polyvinylpyrrolidone and polyvinylpyrrolidone Vinyl alcohol was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd., and the polydimethylsiloxane microwell array mold was purchased from Taizhou Microchip Pharmaceutical Technology Company.
[0068] Prepared chitosan solution (Mw 60kDa, 30% (w / v)), and polyvinylpyrrolidone (Mw 30kDa, 30% (w / v)) and polyvinyl alcohol mixed solution (Mw 30kDa, 30% (w / v) v), 1:1 (w / w)) and fully exhaust the air bubbles by ultrasonic dissolution.
[0069] Set the concentration to 10 7 Each milliliter of 3 milliliters of microalgae mother liquor was centrifuged to remove the medium, then 1 milliliter of chitosan solution was added, the needle mixture was poured into polydimethylsiloxane microwell array molds, and cen...
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