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Foot ulcer pharmaceutical composition

A composition and foot ulcer technology, applied in the field of medicine, can solve the problems of corroding normal tissues, poor debridement effect of dressings, strong toxicity of Hongsheng Dan, etc., and achieve the effect of accelerating wound repair and promoting the blood of tendons

Pending Publication Date: 2022-05-31
天津中医药大学第二附属医院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides a pharmaceutical composition for foot ulcers, which solves the clinical problems of poor debridement effect of dressings, strong toxicity of Hongshengdan and corrosion of normal tissues

Method used

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  • Foot ulcer pharmaceutical composition
  • Foot ulcer pharmaceutical composition
  • Foot ulcer pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] SD rats with a body weight of 200g ± 5g were taken and fed adaptively for one week before being divided into groups for testing.

[0024] The normal group consisted of 8 rats fed normally. The rest of the rats were injected intraperitoneally with streptomycin at 55 mg / kg body weight. Seven days after the injection, the random blood glucose was detected. Those who reached 16.7 mmol / L were randomly divided into groups of 8; After the first day, the medication was started separately, and the medication was changed every other day. The wound area was measured on the 3rd, 7th, 14th, and 21st days after the operation, and the contents of total amino acids, total protein, and lysozyme in the secretions were detected on the 3rd, 7th, and 14th days after the operation. The time when the wound tendon was covered by granulation (tendon granulation) was observed.

[0025] Experiment 1 and Experiment 2 apply the pharmaceutical composition of the present invention; the pharmaceutic...

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Abstract

The invention relates to a foot ulcer medicine composition which comprises 10-20 parts of granulation-promoting adhesive plaster, 8-10 parts of bromelain, 1-2 parts of pearl powder, 1-2 parts of rhizoma bletillae powder and 1-2 parts of pinellia ternate powder, and the bromelain, the pearl powder, the rhizoma bletillae powder and the pinellia ternate powder are used as adulterants to be combined with the granulation-promoting adhesive plaster for use. Or the granulation-promoting adhesive plaster, bromelain, pearl powder, rhizoma bletillae powder and pinellia ternate powder can be mixed to prepare a compound medicament for use. The traditional Chinese medicine composition has the beneficial effects that denatured and necrotic tendon tissues can be removed in a targeted manner through bromelain, pearl powder, rhizoma bletillae powder and pinellia ternate powder, and the granulation-promoting adhesive plaster is supplemented to promote blood conversion of tendons and accelerate wound repair.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a medicinal composition for foot ulcers. Background technique [0002] Diabetes has changed from a rare disease to an epidemic in my country, and the prevalence of diabetic foot has also increased significantly. The incidence of diabetic foot in my country's diabetic patients over 50 years old is as high as 8.1%. It is estimated that every 20 seconds in the world, a diabetic patient has a limb amputation; the annual mortality rate of diabetic foot ulcer patients is as high as 11%, while the mortality rate of amputation patients is as high as 22%; domestic and foreign studies have shown that the cost of diabetic foot is huge, accounting for about 10% of the total diabetes one-third of medical expenses. Therefore, diabetic foot is one of the main causes of disability and death in diabetic patients, and it is also a major public health problem that causes a heavy burden on society. [0003...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61P17/02A61K35/618A61K35/36A61K35/586A61K33/06A61K33/30A61K35/644
CPCA61K38/4873A61K35/618A61K36/898A61K36/8888A61K35/36A61K35/586A61K36/804A61K36/232A61K33/06A61K33/30A61K35/644A61P17/02C12Y304/22004A61K2300/00Y02A50/30
Inventor 张朝晖朱朝军孙旭马静徐强孙俊超孙玉芝
Owner 天津中医药大学第二附属医院
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