Composition as well as preparation method and application thereof

A technology of composition and hydrate, which is applied in the direction of drug combination, pharmaceutical formula, medical preparation of non-active ingredients, etc., can solve the problem of taste masking of the undisclosed dextromethorphan quinidine composition, and achieve the improvement of taste, bitterness and numbing , high safety, and the effect of improving the medication experience

Active Publication Date: 2022-06-03
北京剂泰医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above two taste-masking related documents do not discl

Method used

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  • Composition as well as preparation method and application thereof
  • Composition as well as preparation method and application thereof
  • Composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Gourge legal preparation binary compounds: Take an appropriate amount of hydroceroide, Mishafin and sulfininin, add cyclic paste, add an appropriate amount of purified water, grind, dry in 60 ° C, and dry. The ethylene -saturated ethanol solution was washed in the 60 ℃ oven again. After crushing and sieved, the right Michafen Ring Wastebulin and Quinindin Circle Playing were obtained.

[0025] The packaging rate of the obtained packet compound is detected, and the manual taste method is used to evaluate the mask effect of the cyclical essence. The result is shown in Table 1.

[0026] Artificial taste method: Volunteers do not eat, drink, chew gum at least 1h before testing, and rinse with exfoliating water more than 3 times. Volunteers include the sample in the mouth, spit out after 10s, rinse the mouth with deodorized water to the mouth without odor (at least 10 times), and then taste the taste. According to the "extremely bitter, bitter, slightly bitter, not bitter, tongue, and s...

Embodiment 2

研磨法制备三元包合物:称取氢溴酸右美沙芬和硫酸奎尼丁后混合,采用实施例1中的制备方法,制备环糊精、氢溴酸右美沙芬和硫酸奎尼丁Moorebi is 3: 1: 0.236 Right Michafininin Dingtin Circle Pack. Test the packaging rate of the right Michafininin pockets that are obtained by different circles, and the results are shown in Table 2.

[0029] The results showed that the packets of the ternary packets on the right Michafin and Quinine were better. Compared with binary compounds, the triangle compounds significantly improved the packaging rate for right Michafin and Quinindin. Especially the β-cyclic paste three-dollar compounds, the packaging rate of Quinine even increased by more than 10 times.

Embodiment 3

The aqueous solution of the water system prepares a ternary compound: It is called an appropriate amount of circular paste, and the hydromodiacomy acid right Mishafin and sulfinine are added to make the cyclical, hydromodium bromide, and sulfinin Dindinmore The ratio is 3: 1: 0.236, add an appropriate amount of exfoliating water, stir at 60 ° C until the mixture is completely dissolved, and freeze the solution to freeze and dry it. The obtained frozen dried powder was washed with a saturated ethanol solution saturated in a circular paste. After filtering, it was dried in a 60 ° C oven. Test the packaging rate of the right Michafininin pockets that are obtained by different circles, and the results are shown in Table 3.

[0031] The results show that the water-solution method of this embodiment is used to use the hydroxyhopropyl-β-cyclone-β-compounds to packed the right enveloping rate of the right Misha and Finkikinin The packets of the packets are low in packed on the right Mis...

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Abstract

The invention provides a dextromethorphan quinidine composition as well as a preparation method and application of the dextromethorphan quinidine composition. According to the dextromethorphan and quinidine composition provided by the invention, the bitter taste and the numb taste of dextromethorphan and quinidine are improved by adding cyclodextrin, meanwhile, the dextromethorphan and quinidine composition provided by the invention is easily prepared into various oral preparations easy to swallow, the problem that patients with nervous system diseases are difficult to swallow is solved, and the medication experience can be greatly improved.

Description

Technical field [0001] The invention involves the field of drug preparations, which specifically involves a composition and preparation methods and applications containing the right Mishafinininpin purse. Background technique [0002] Demoninine and sulfininininine hydride is a compound drug developed by Avanir Pharmaceuticals Inc. It was first approved by the FDA for the first time in October 2010 in October 2010. This drug is the first and only drug for the treatment of PBA. PBA is also known as emotional incontinence. It is mainly secondary to Parkinson's disease, multiple sclerosis, muscle atrophic spinal cord sclerosis and stroke. Suddenly there is unconscious crying or laughing. [0003] The taste of You Meishafen and Quinin is very bad, bitter and numb. The currently listed dosage form is capsules. Patients with neurological diseases are often accompanied by symptoms such as swallowing difficulties and saliva. Studies have shown that the incidence of Parkinson's patients w...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K31/485A61K31/4709A61P25/00A61P25/28
CPCA61K47/6951A61K31/485A61K31/4709A61P25/00A61P25/28A61K2300/00
Inventor 赖青海王孝便李海燕王文首赖才达
Owner 北京剂泰医药科技有限公司
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