Stable liposome wrapping process and application thereof

Abstract

The invention discloses a stable liposome coating process which comprises the following steps: mixing an oil phase and an organic solvent, putting the mixture into a rotary evaporator to evaporate the organic solvent to dryness to form a film, adding a water phase into the film for homogenization treatment, and extruding by a liposome extruder to obtain the stable liposome coating. According to the invention, the types of phospholipid and fat-soluble substances are optimized, and lecithin and hydrogenated phosphatidylcholine are combined and compounded, so that the stability of the water-soluble substances in a fat-soluble film is improved, and the solubilization expansion of the coated liposome is reduced; and moreover, the liposome does not contain Tween and Span surfactants, so that the formed liposome has a good skin feeling after being in contact with the skin, and the problem of skin tension cannot be caused after the liposome is used.

Description

technical field [0001] The invention relates to a stable liposome encapsulation process, relates to A61K, and in particular relates to the field of preparations for dressing. Background technique [0002] In the use of skin care cosmetics, many substances with good efficacy are not easily absorbed by the skin due to their large molecular structure. After using skin care products, they are simply attached to the surface of the skin and cannot penetrate deep into the skin to achieve good results, resulting in the loss of nutrients. Waste, now through the liposome encapsulation technology, macromolecular substances can be encapsulated through the skin surface and into the interior of the skin to achieve good skin care effects, but the stability of liposomes is not good, solubilization may occur during transportation and storage. For the problem identified by the active ingredient, it was found that the stability of the liposome can be increased by adding a surfactant, but in th...

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Problems solved by technology

[0002] In the use of skin care cosmetics, many substances with better efficacy are not easily absorbed by the skin due to their large molecular structure. After using skin care products, they simply adhere to the skin surface and cannot penetrate deep into the skin to achieve good results, resulting in the loss of nutrients. Waste, now through liposome encapsulation technology, macromolecular substances can be wrapped and penetrate the skin surface into the skin to achieve a good skin care effect, but the stability of liposomes is not good, solubilization may occur during transportation and storage, For the problem of effective ingredients, some people found that the stability of liposomes can be increased by adding surfactants, but in the surfactant system, nano-liposomes may swell and dissolve.

[0003] Chinese invention patent CN201811284818.5 discloses a preparation method of cosmetic liposomes with combined nutrients. Ethylene-maleic acid copolymer and phospholipids form a coating layer together, which improves the stability of the coating layer, but the liposomes formed The particle size is 220-260nm, the particle size is relatively large, it is not easy to be absorbed by the skin and stored stably

The Journal of Southeast University, Volume 37, No. 1, January 2007, disclosed the preparation of tea polyphenol liposomes by surfactants. The stability of liposomes can be increased by introducing surfactants Span and Tween, but the surface The introduction of active agents will lead to a decline in the skin feel of the cosmetics, a tight feeling, and a decrease in the comfort of use