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Leonurine, polygonatum polysaccharide and deoxynojirimycin pharmaceutical composition and application thereof

A technology of deoxynojirimycin and polysaccharide polysaccharide is applied in the directions of drug combination, active ingredients of heterocyclic compounds, and pharmaceutical formulations, which can solve problems such as many adverse reactions, and achieve the effects of less toxic side effects, high content of active ingredients, and improving blood clots.

Pending Publication Date: 2022-06-24
安徽省科技成果转化促进中心(安徽省科学技术研究院)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently known antithrombotic drugs have many adverse reactions, so it is necessary to find new drugs to treat diabetes and thrombosis. Traditional Chinese medicine plays an important role in the treatment of thrombosis. Activating blood circulation and removing blood stasis is the golden rule of TCM antithrombotic therapy

Method used

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  • Leonurine, polygonatum polysaccharide and deoxynojirimycin pharmaceutical composition and application thereof
  • Leonurine, polygonatum polysaccharide and deoxynojirimycin pharmaceutical composition and application thereof
  • Leonurine, polygonatum polysaccharide and deoxynojirimycin pharmaceutical composition and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation method of the pharmaceutical composition of leonurine, polysaccharide polysaccharide and deoxynojirimycin of the present invention is as follows: weigh 75 g of leonurine, 50 g of polysaccharide polysaccharide, 500 g of deoxynojirimycin, 290 g of starch, 45 g of maltodextrin, and 40 g of mannitol. Mix well with a 100-mesh sieve, add an appropriate amount of distilled water to make soft materials, pass through a 18-mesh sieve for granulation, dry at 45-60°C and pass through a 16-mesh sieve to granulate, fill the capsules to make capsules (1g / capsule), or press into tablets It can be made into tablets (1 g / tablet), or filled into granules (10 g / pack), in the form of granules or tablets or capsules.

Embodiment 2

[0038] The preparation method of the pharmaceutical composition of leonurine, polysaccharide polysaccharide and deoxynojirimycin of the present invention is as follows: weigh 93.75 g of leonurine, 50 g of polysaccharide polysaccharide, 625 g of deoxynojirimycin, 175 g of starch, 30 g of maltodextrin, and 26.25 g of mannitol , pass through a 100-mesh sieve and mix well, add an appropriate amount of distilled water to make soft materials, pass through a 18-mesh sieve for granulation, dry at 45-60°C and pass through a 16-mesh sieve to granulate, fill the capsules to make capsules (1g / capsule), or Tablets are made into tablets (1 g / tablet), or filled into granules (10 g / pack), and the formulations are in the form of granules or tablets or capsules.

Embodiment 3

[0040] The preparation method of the pharmaceutical composition of leonurine, polysaccharide polysaccharide and deoxynojirimycin of the present invention is as follows: weighing 90 g of leonurine, 45 g of polysaccharide polysaccharide, 720 g of deoxynojirimycin, 90 g of starch, 30 g of maltodextrin, and 20 g of mannitol, Mix well with a 100-mesh sieve, add an appropriate amount of distilled water to make soft materials, pass through a 18-mesh sieve for granulation, dry at 45-60°C and pass through a 16-mesh sieve to granulate, fill the capsules to make capsules (1g / capsule), or press into tablets It can be made into tablets (1 g / tablet), or filled into granules (10 g / pack), in the form of granules or tablets or capsules.

[0041] The pharmaceutical composition of leonurine, polysaccharide polysaccharide and deoxynojirimycin has the effect of treating diabetes, lowering blood sugar and improving thrombus. These pharmacological effects are confirmed by the following pharmacodynami...

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Abstract

The invention discloses a pharmaceutical composition of leonurine, polygonatum sibiricum polysaccharide and deoxynojirimycin and application of the pharmaceutical composition. The pharmaceutical composition comprises leonurine, polygonatum sibiricum polysaccharide and deoxynojirimycin in a weight ratio of (1.5-2): 1: (10-16). Pharmacological experiments prove that the composition can effectively reduce blood sugar and effectively inhibit thrombus, can be used for preparing drugs for treating diabetic basic diseases combined with thrombus, and has the advantages of being simple in formula, high in active ingredient content, safe, effective and the like.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, in particular to the application of leonurine, polysaccharide polysaccharide and deoxynojirimycin in preparing medicines for preventing and / or treating diabetes-related diseases and / or disorders. Background technique [0002] Diabetic patients have no obvious early symptoms, and are accompanied by a variety of different complications, which can induce damage to microvascular and large blood vessels, and also cause damage to the eyes, feet, heart, and brain. The content of four coagulation and fibrinolysis indexes in the plasma of diabetic patients was significantly higher than that of non-diabetic patients, so the blood of diabetic patients had hypercoagulability. Factors such as high insulin, high blood sugar, and insulin resistance in diabetic patients will make the endothelial cells of diabetic patients more susceptible to damage than normal people, resulting in functional disorders and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/10A61P7/02A61K31/235A61K31/445
CPCA61K31/715A61K31/235A61K31/445A61P3/10A61P7/02A61K2300/00
Inventor 许舒雯杜李继赵辉盛晓玲王子丽汪业梅
Owner 安徽省科技成果转化促进中心(安徽省科学技术研究院)
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