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Multifunctional coating material with high chemical stability as well as preparation method and application of multifunctional coating material

A multi-functional coating, chemical stability technology, applied in coatings, polyamide coatings, pharmaceutical formulations, etc., can solve the problems of restricting the functional modification of the coating surface and the speed of phenol quinone products cannot be well coordinated. , to achieve the effect of increasing chemical stability and adhesion performance, improving binding efficiency, and expanding application fields

Active Publication Date: 2022-06-28
DONGGUAN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the complex chemical reaction of phenolic amines depends on the time scale and the change of environmental pH, and the rate of oxidation to form phenolic quinone products is not well coordinated, which in turn generates a large number of phenolic oligomers. Application under oxidizing conditions
In addition, the secondary reactive primary amino groups retained on the surface of traditional catecholamine coatings are mainly contributed by phenolic compounds, and the limited content of primary amino groups restricts the further functional modification of the coating surface.

Method used

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  • Multifunctional coating material with high chemical stability as well as preparation method and application of multifunctional coating material
  • Multifunctional coating material with high chemical stability as well as preparation method and application of multifunctional coating material
  • Multifunctional coating material with high chemical stability as well as preparation method and application of multifunctional coating material

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preparation example Construction

[0041] An embodiment of the present invention provides a method for preparing a multifunctional coating material with strong chemical stability, comprising the following steps:

[0042] S1. Preparation of modified amine compounds modified by functionalized molecules

[0043] After activating the carboxyl group of the acidic compound containing the functional group, it reacts with the amino compound to obtain a modified amino compound, and the functional group is introduced by using the acidic compound.

[0044] In the actual operation process, the process of preparing the modified amine-based compound includes: dissolving the acidic compound containing functional groups in a buffer solution with a pH value of 4-10, and performing an activation reaction with a condensing agent at 0-240 ° C for 0.001 h-240h; and then react with an amine compound with a concentration of 0.01ng / mL-5g / mL at 0-240°C for 0.001h-240h, so that the carboxyl group and the amine group can fully react. Di...

Embodiment 1

[0071] The present embodiment provides a method for preparing a multifunctional coating material with strong chemical stability. 316L stainless steel is selected as the base material prepared by the coating, which includes the following steps:

[0072] (1) Molecular synthesis of amine compounds modified by functionalized molecules

[0073] The specific steps include: dissolving 1 mg / mL of 4-pentynoic acid in MES buffer solution with pH adjusted to 5.6, adding EDC and NHS (the molar ratio of EDC to carboxyl group is 5:1, and the molar ratio of NHS to carboxyl group is 1:1: 1, the same below), react at 37°C for 0.5h. Then polyallylamine (weight-average molecular weight 8,000, 20 wt.% aqueous solution) with a molar ratio of carboxyl group to amine group was added, and the synthesized molecule (4-PA / pPAM) was purified by dialysis after reacting at 37 °C for 24 h. spare.

[0074] (2) Condensation of rich phenol-amine compounds

[0075] Dissolve 1 mg / mL hydrogenated caffeic acid in...

Embodiment 2

[0079] The present embodiment provides a method for preparing a multifunctional coating material with strong chemical stability. 316L stainless steel is selected as the base material prepared by the coating, which includes the following steps:

[0080] (1) Molecular synthesis of amine compounds modified by functionalized molecules

[0081] The specific steps include: dissolving 1 mg / mL of 4-pentynoic acid in an MES buffer solution whose pH is adjusted to 5.6, adding EDC and NHS, and reacting at 37° C. for 0.5 h. Then polyallylamine (weight-average molecular weight 17,000, 20 wt.% aqueous solution) with a molar ratio of carboxyl groups to amine groups was added, and the synthesized molecule (4-PA / pPAM) was purified by dialysis after reacting at 37 °C for 24 h. spare.

[0082] (2) Condensation of rich phenol-amine compounds

[0083] Dissolve 1 mg / mL hydrogenated caffeic acid in a completely anaerobic MES buffer solution with pH adjusted to 5.6, add EDC and NHS, react at 37 °C ...

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Abstract

The invention discloses a multifunctional coating material with high chemical stability as well as a preparation method and application thereof, and relates to the technical field of biological materials. Firstly, an acidic compound containing a functional group reacts with an amino compound to obtain a modified amino compound containing the functional group, then a phenolic compound containing carboxyl reacts with the modified amino compound to obtain a phenol-amine-rich functional compound, and the phenol-amine-rich functional compound is used for forming the coating on a base material. The coating is obtained by depositing a carboxyl-containing phenolic compound and a modified amino compound under alkalescence under the condition of fully protecting a phenolic hydroxyl group. The modified amino compound is introduced, so that the defect that traditional catechol polymerization depends on the oxidation speed of phenolic hydroxyl groups and products is overcome, physical assembly of traditional phenolic oligomers is replaced with more stable chain chemical crosslinking, and the bonding efficiency of the phenolic hydroxyl groups and a substrate interface is effectively improved; and the chemical stability and the adhesion property of the coating are also improved.

Description

technical field [0001] The present invention relates to the technical field of biological materials, in particular to a multifunctional coating material with strong chemical stability, a preparation method and application thereof. Background technique [0002] In nature, inspired by the adhesion molecules of marine mussels, it was found that the catechol compounds in the mussel byssal protein played the most important role in the adhesion process. When byssin interacts with the surface, a large number of catechol groups interact with the interface through covalent and non-covalent adhesion, and a large number of charge-charge, π-π, cation-π, coordination, hydrogen bonds and hydrophobic interactions in the adhesion process. [0003] At present, the complex chemical reaction of phenolamines depends on the time scale and environmental pH changes, and the rate of oxidation to form phenolquinone products cannot be well coordinated, and the formation of a large number of phenolic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F126/02C08F8/00C08G69/48C09D139/00C09D139/02C09D177/04A61L29/08A61L29/14A61L29/16A61L31/08A61L31/10A61L31/14A61L31/16
CPCC08F8/00C08G69/48C09D139/00C09D139/02C09D177/04A61L29/08A61L29/085A61L29/16A61L29/14A61L31/08A61L31/10A61L31/14A61L31/16A61L2420/02A61L2400/18C08F126/02Y02E60/10
Inventor 杨志禄杜泽煜黄楠牟小辉王颖张文泰杨梦毅
Owner DONGGUAN PEOPLES HOSPITAL