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Microfluidic technology-based intelligent preparation control method and equipment for biological vaccines

A microfluidic technology and control method technology, which is applied to sanitary equipment, chemical instruments and methods, control/regulation systems for toilets, etc., can solve the problems of cumbersome process, difficult control, poor preparation process and equipment tolerance, etc. Prevent errors, avoid cumbersome operations, and control the effect of preparation

Active Publication Date: 2022-07-15
苏州艾特森制药设备有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current conventional preparation method is usually a batch method, which requires multi-step operations, the process is cumbersome, and it is difficult to complete high-quality linear amplification in a short time; while the existing preparation process is mostly simple and scattered equipment that requires manual operation, which is difficult to control , the precise control of the fluid cannot be guaranteed; moreover, the inclusiveness of the existing preparation process and equipment is very poor, and the limited preparation conditions are difficult to meet the application conditions of high flow rate production

Method used

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  • Microfluidic technology-based intelligent preparation control method and equipment for biological vaccines
  • Microfluidic technology-based intelligent preparation control method and equipment for biological vaccines
  • Microfluidic technology-based intelligent preparation control method and equipment for biological vaccines

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Embodiment 1

[0051] Reference attached Figure 1-4 The present embodiment provides a method and device for intelligently preparing and controlling biological vaccines based on microfluidic technology. An intelligent microfluidic control preparation system for biological vaccines is adopted, and the preparation system includes a preparation unit and a control unit.

[0052] The preparation unit includes a two-phase infusion pipeline 1 for inputting the liquid phase, a pump that is the same in number as the infusion pipeline 1 and supplies liquid to the infusion pipeline 1 in one-to-one correspondence, and at least two pumps connected in parallel to the two-phase infusion pipeline 1. A microfluidic chip for liquid phase mixing, reaction and incubation, and a product outlet 2 that communicates with the microfluidic chip and is used for outputting products. Specifically, refer to the appendix figure 1 , the pump is arranged at the input end of the corresponding infusion pipeline 1, which can ...

Embodiment 2

[0087] Refer to the attached Figure 5 The difference between this embodiment and the first embodiment is that the infusion pipeline 1 has more than two phases. Assuming that N is an integer greater than or equal to 2, the infusion pipeline 1 has N+1 phases and is divided into N levels. The first level has Two-phase infusion pipeline 1, all the other stages except the first-stage infusion pipeline 1 have one-phase infusion pipeline 1; the microfluidic chip is divided into N stages, and each stage has a set of microfluidic chips , each group has at least two microfluidic chips connected in parallel, the input ends of the first-stage microfluidic chips are respectively connected to the two-phase first-stage infusion pipeline 1 through the corresponding valve 7 in a connected or disconnected manner, the first stage The input end of the n-stage microfluidic chip can be connected or disconnected to the output end of the n-1 stage microfluidic chip and the n-th stage infusion pipeli...

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Abstract

The invention relates to an intelligent biological vaccine preparation control method and equipment based on a micro-fluidic technology, and adopts an intelligent micro-fluidic preparation system for biological vaccines. The preparation system comprises at least two liquid conveying pipelines, at least two micro-fluidic chips connected between the liquid conveying pipelines in parallel, a main control module, a monitoring module used for monitoring the flow speed, pressure and temperature, a pump used for supplying liquid, a valve used for opening and closing the pipelines and a temperature control module used for adjusting the temperature, and the control method of the production mode of the preparation system comprises the steps that parameters are set, starting preparation; the monitoring module monitors real-time parameters; the main control module compares the real-time parameters with set parameters and controls the pump, the valve and the temperature control module to adjust; and stopping preparation when the liquid actually participating in preparation reaches a set value, then cleaning and stopping operation. According to the invention, process parameters can be automatically regulated and controlled in real time in the preparation process, accurate, efficient and controllable intelligent preparation of biological vaccines is realized, and guarantee is provided for industrial linear amplification.

Description

technical field [0001] The invention relates to an intelligent preparation control method and equipment for biological vaccines based on microfluidic technology, which are suitable for the field of medicine and biotechnology. Background technique [0002] As a preventive drug for various major diseases, biological vaccines have always been related to human health, and many sudden diseases often die out with the successful development of targeted vaccines. Therefore, the research and development of biological vaccines has always been the top priority in the pharmaceutical field. The traditional preparation process of biological vaccines often focuses on how to express and efficiently separate and extract proteins or nucleic acids. The process steps and equipment involved are very mature. After the proteins or nucleic acids are prepared as APIs, the subsequent The preparation process generally only needs to perform conventional adsorption with adjuvants, and the research on h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F33/81A61L2/07A61L2/24B01F33/30B01F35/10B01F35/11B01F35/221B01F35/71G05D27/02B01F101/22
CPCA61L2/07A61L2/24G05D27/02A61L2202/14Y02P90/02
Inventor 叶玉林
Owner 苏州艾特森制药设备有限公司
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