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High-rigidity, high-strength and high-toughness lubricating copolymerized hydrogel as well as preparation method and application thereof

A high-strength, high-rigidity technology, applied in prosthetics, medical science, etc., can solve problems affecting the strength of hydrogels, achieve excellent mechanical properties, broaden the application range, and simple operation

Active Publication Date: 2022-07-29
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, lubricity requires the addition of a higher proportion of acryloylcarboxybetaine (CBAA), which affects the strength of the hydrogel

Method used

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  • High-rigidity, high-strength and high-toughness lubricating copolymerized hydrogel as well as preparation method and application thereof
  • High-rigidity, high-strength and high-toughness lubricating copolymerized hydrogel as well as preparation method and application thereof
  • High-rigidity, high-strength and high-toughness lubricating copolymerized hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Step 1: Weigh 0.035g NASC and 0.025g CBAA with an analytical balance and place them in a centrifuge tube, add a certain amount of dimethyl sulfoxide (DMSO) and deionized water (H 2 O) mixed solvent (DMSO: 0.3 mL; H 2 0:0.7mL), heated to dissolve to form a homogeneous solution, add a certain amount of photoinitiator (1173:0.6μL), and then put it into a UV crosslinker for photoinitiation for 40-60min to form gel P (NASC-CBAA) .

[0033] Step 2, add a certain amount of NASC and CBAA (NASC: 0.17g; CBAA: 0.03g) to the gel formed in step 1, then heat until it becomes a uniform sol state, add a certain amount of photoinitiator ( 1173: 2 μL) in an oven to let stand to remove air bubbles.

[0034] In step 3, the sol formed in step 2 is poured into a mold, polymerized by light for 40-60 minutes, and then soaked in water to obtain a high-strength, high-toughness, and high-modulus lubricating hydrogel.

Embodiment 2

[0036] Step 1: Weigh 0.035g NASC and 0.025g CBAA with an analytical balance and place them in a centrifuge tube, add a certain amount of dimethyl sulfoxide (DMSO) and deionized water (H 2 O) mixed solvent (DMSO: 0.3 mL; H 2 0:0.7mL), heated to dissolve to form a homogeneous solution, add a certain amount of photoinitiator (1173:0.6μL), and then put it into a UV crosslinker for photoinitiation for 40-60min to form gel P (NASC-CBAA) .

[0037] Step 2, add a certain amount of NASC and CBAA (NASC: 0.34g; CBAA: 0.06g) to the gel formed in step 1, then heat until it becomes a uniform sol state, add a certain amount of photoinitiator ( 1173: 2 μL) in an oven to let stand to remove air bubbles.

[0038] In step 3, the sol formed in step 2 is poured into a mold, polymerized by light for 40-60 minutes, and then soaked in water to obtain a high-strength, high-toughness, and high-modulus lubricating hydrogel.

Embodiment 3

[0040] Step 1: Weigh 0.035g NASC and 0.025g CBAA with an analytical balance and place them in a centrifuge tube, add a certain amount of dimethyl sulfoxide (DMSO) and deionized water (H 2 O) mixed solvent (DMSO: 0.3 mL; H 2 0:0.7mL), heated to dissolve to form a homogeneous solution, add a certain amount of photoinitiator (1173:0.6μL), and then put it into a UV crosslinker for photoinitiation for 40-60min to form gel P (NASC-CBAA) .

[0041] Step 2, add a certain amount of NASC and CBAA (NASC: 0.51g; CBAA: 0.09g) to the gel formed in step 1, then heat until it becomes a uniform sol state, add a certain amount of photoinitiator ( 1173: 2 μL) in an oven to let stand to remove air bubbles.

[0042] In step 3, the sol formed in step 2 is poured into a mold, polymerized by light for 40-60 minutes, and then soaked in water to obtain a high-strength, high-toughness, and high-modulus lubricating hydrogel.

[0043] The as-prepared hydrogel exhibited a good mechanical property, such ...

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Abstract

The invention provides a high-rigidity, high-strength and high-toughness lubricating copolymerized hydrogel and a preparation method and application thereof.The preparation method comprises the steps that N-acryloyl urea amine and acryloyl carboxylic acid betaine are added into a mixed solvent of dimethyl sulfoxide and deionized water to be heated and dissolved, a mixed solution is obtained, a photoinitiator is added into the mixed solution for a photo-initiation polymerization reaction, and the high-rigidity, high-strength and high-toughness lubricating copolymerized hydrogel is obtained. Gel P is obtained; adding N-acryloyl urea amine and acryloyl carboxylic acid betaine into the gel P, heating and dissolving to obtain sol, adding a photoinitiator, and standing in a drying oven to remove bubbles to obtain bubble-free sol; the sol is subjected to photo-initiation polymerization and soaked in water, and then the high-rigidity, high-strength and high-toughness lubricating copolymerized hydrogel is obtained. Or the bubble-free sol is transferred into a charging barrel of a 3D printer for 3D printing, and hydrogel scaffolds in different shapes can be printed. The N-acryloyl urea amine monomer with relatively high concentration is added in a monomer post-compensation manner, so that the hydrogel is endowed with excellent mechanical properties.

Description

technical field [0001] The invention relates to the technical field of lubricating hydrogel preparation, and more particularly to a high-rigidity, high-strength, high-toughness lubricating copolymer hydrogel and a preparation method and application thereof. Background technique [0002] Soft bearing tissue plays an important role in the body, but due to the lack of vascular structure, its self-healing performance is poor when it is injured. As a water-rich material, hydrogel has good biocompatibility and has important application value in soft tissue replacement. [0003] In recent years, high-rigidity, high-strength, and high-toughness hydrogels have made breakthroughs. However, due to the contradiction between lubrication and strength, it is difficult for high-strength hydrogels to achieve good lubricity. Hydrogels often do not have excellent mechanical properties, because high strength and high rigidity require relative hydrophobicity of molecular chains, while lubricity...

Claims

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Application Information

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IPC IPC(8): C08F265/10C08F220/60C08F220/58A61L27/16A61L27/50A61L27/52
CPCC08F265/10A61L27/16A61L27/52A61L27/50A61L2430/06C08F220/603C08F220/58C08L51/003
Inventor 刘文广范川川
Owner TIANJIN UNIV
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