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Composite catheter material doped with mechanoluminescent material and preparation method of composite catheter material

An electroluminescence and catheter technology, which can be applied to luminescent materials, catheters, chemical instruments and methods, etc., can solve the problems of blood coagulation vascular stenosis, blocked blood flow, etc., and achieve simple and convenient preparation, maintain patency, and excellent biocompatibility. Effect

Active Publication Date: 2022-08-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reported pressure sensor is a very complex wireless communication platform and is externally connected to the stent, which can block the blood flow to some extent, leading to blood coagulation and restenosis.

Method used

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  • Composite catheter material doped with mechanoluminescent material and preparation method of composite catheter material
  • Composite catheter material doped with mechanoluminescent material and preparation method of composite catheter material
  • Composite catheter material doped with mechanoluminescent material and preparation method of composite catheter material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1) Mix 2 mL of polydimethylsiloxane (PDMS) and 250 mg of CaZnOS:Nd 3+ The powder is stirred and mixed evenly in a 1.5mL centrifuge tube;

[0038] 2) Add 0.2 mL of hardener poly(dimethyl-methylhydrogensiloxane) to the mixed solution in 1) and stir well;

[0039] 3) Put the mixed solution in 2) into an incubator at 60°C to solidify for 1 hour until a viscous liquid is formed;

[0040] 4) Immerse the metal rod mold with a diameter of 0.8 mm into the viscous solution in 3) and place it for 10 minutes. After dipping, take out the metal rod mold and place it vertically in an 80°C incubator for curing for 20 minutes;

[0041] 5) Re-immerse the solidified metal rod mold in 4) into the viscous liquid in 3), place for 10 minutes, take out the metal rod mold after dipping, place it vertically in an 80°C incubator to cure for 20 minutes, and repeat this step 10 times ;

[0042] 6) Place the metal rod mold in 5) vertically in an 80°C incubator for curing for 12h;

[0043] 7) dem...

Embodiment 2

[0046] 1) Mix 2 mL of polydimethylsiloxane (PDMS) and 500 mg of CaZnOS:Nd 3+ The powder is stirred and mixed evenly in a 1.5mL centrifuge tube;

[0047] 2) Add 0.2 mL of hardener poly(dimethyl-methylhydrogensiloxane) to the mixed solution in 1) and stir well;

[0048] 3) Put the mixed solution in 2) into an incubator at 60°C to solidify for 1 hour until a viscous liquid is formed;

[0049]4) Immerse the metal rod mold with a diameter of 0.8 mm into the viscous solution in 3) and place it for 10 minutes. After dipping, take out the metal rod mold and place it vertically in an 80°C incubator for curing for 20 minutes;

[0050] 5) Re-immerse the solidified metal rod mold in 4) into the viscous liquid in 3), place for 10 minutes, take out the metal rod mold after dipping, place it vertically in an 80°C incubator to cure for 20 minutes, and repeat this step 10 times ;

[0051] 6) Place the metal rod mold in 5) vertically in an 80°C incubator for curing for 12h;

[0052] 7) demo...

Embodiment 3

[0055] 1) Mix 2 mL of polydimethylsiloxane (PDMS) and 1000 mg of CaZnOS:Nd 3+ The powder is stirred and mixed evenly in a 1.5mL centrifuge tube;

[0056] 2) Add 0.2 mL of hardener poly(dimethyl-methylhydrogensiloxane) to the mixed solution in 1) and stir well;

[0057] 3) Put the mixed solution in 2) into an incubator at 60°C to solidify for 1 hour until a viscous liquid is formed;

[0058] 4) Immerse the metal rod mold with a diameter of 0.8 mm into the viscous solution in 3) and place it for 10 minutes. After dipping, take out the metal rod mold and place it vertically in an 80°C incubator for curing for 20 minutes;

[0059] 5) Re-immerse the solidified metal rod mold in 4) into the viscous liquid in 3), place for 10 minutes, take out the metal rod mold after dipping, place it vertically in an 80°C incubator to cure for 20 minutes, and repeat this step 10 times ;

[0060] 6) Place the metal rod mold in 5) vertically in an 80°C incubator for curing for 12h;

[0061] 7) de...

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Abstract

The invention discloses a composite conduit material doped with a mechanoluminescent material and a preparation method of the composite conduit material. Comprising a matrix material and a mechanoluminescent material, the matrix material adopts polydimethylsiloxane, Teflon and other artificially synthesized materials or natural materials, and the mechanoluminescent material adopts CaZnOS: Nd < 3 + > and other mechanoluminescent materials; the preparation method comprises the following steps: mixing to form a mixed solution, adding a hardening agent, curing at constant temperature until viscous liquid is formed, dipping a metal rod mold into the viscous liquid, taking out after dipping, curing at constant temperature, continuously repeating the steps for many times, and finally demolding to obtain the composite conduit material. The composite catheter material disclosed by the invention emits near-infrared light signals under the condition of applying external force, can be implanted into an in-vivo blood vessel, and is used for monitoring blood pressure, blood vessel stenosis and the working state of an artificial blood vessel implant.

Description

technical field [0001] The invention belongs to a composite material and a preparation method thereof in the field of biomedical materials, in particular to a composite catheter material doped with electroluminescent materials and a preparation method thereof. Background technique [0002] Cardiovascular diseases (CVDs) are common diseases that seriously threaten the health of human beings, especially the middle-aged and elderly people over 50 years old. Peripheral vascular disease and ischemic heart disease are two related and fairly common cardiovascular diseases. Occlusion or stenosis of small diameter vessels can lead to these diseases. Implantation of artificial vascular grafts (AVGs) or stents is currently the main treatment strategy. However, due to the different vascular status of patients, implanted AVGs frequently occlude, thrombosis, or restenosis, leading to implant failure and life-threatening patients. At the same time, there are limited methods for rapid, r...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L29/02A61L29/14C09K11/56C09K11/02
CPCA61L29/06A61L29/02A61L29/14C09K11/7756C09K11/025C08L83/04
Inventor 毛传斌刘项宇杨明英
Owner ZHEJIANG UNIV