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Anti-tumor combined composition, application thereof and anti-tumor drug

A composition and anti-tumor technology, applied in the directions of anti-tumor drugs, drug combinations, antibodies, etc., can solve the problems of increased cytokines and insufficient curative effect, and achieve the effect of improving the therapeutic effect and enhancing the inhibitory effect.

Pending Publication Date: 2022-08-09
HEZE UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, immunotherapy regulates the immune system in the treatment of tumors, such as overactive immune cells in the body; increased cytokines that promote inflammation; increased autoimmune antibodies, etc., resulting in inaccurate curative effects. Immunocombination therapy to improve its curative effect and exert its immunotherapeutic effect mechanism

Method used

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  • Anti-tumor combined composition, application thereof and anti-tumor drug
  • Anti-tumor combined composition, application thereof and anti-tumor drug
  • Anti-tumor combined composition, application thereof and anti-tumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The anti-tumor combination composition provided in this example includes the following combination drugs: an active ingredient (SHT-CFQ) and an anti-PDL1 monoclonal antibody (anti-PDL1); the active ingredient includes berberine in a mass ratio of 1:1:1 Compounds, Baicalin Compounds and Phellodendron Compounds.

Embodiment 2

[0049] The anti-tumor combination composition provided in this example includes the following combination drugs: the active ingredients of the extract (SHT-TQW) and the anti-PDL1 monoclonal antibody (anti-PDL1); the active ingredients of the extract include a mass ratio of 1:1:1 The total extracts of Coptis chinensis, Scutellaria baicalensis and Treats.

Embodiment 3

[0051] The anti-tumor combination composition provided in this example includes the following combination drugs: an active ingredient (SHT-CFQ) and an anti-TIM3 monoclonal antibody (anti-TIM3); the active ingredient includes berberine in a mass ratio of 1:2:1 Compounds, Baicalin Compounds and Phellodendron Compounds.

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Abstract

The invention provides an anti-tumor combined composition, application thereof and an anti-tumor drug, and relates to the technical field of anti-tumor drugs. The anti-tumor combined composition comprises the following combined medicines: an effective component and an immune checkpoint inhibitor, the effective components comprise at least one of berberine, baicalin and phellodendrine. The invention further provides application of the anti-tumor combined composition and an anti-tumor drug prepared from the anti-tumor combined composition. The traditional Chinese medicine composition can be used for treating cancers in a drug combination manner, and can effectively enhance the inhibition effect on tumors and improve the treatment effect on the tumors.

Description

technical field [0001] The present invention relates to the technical field of anti-tumor drugs, in particular, to an anti-tumor combination composition and its application and anti-tumor drugs. Background technique [0002] Cancer refers to malignant tumors originating from epithelial tissue. Recently, according to the statistics of "CA CANCER J CLIN", in many countries, cancer has become the first or second leading cause of human life-threatening. Cancer treatment methods include surgery, chemotherapy, radiotherapy, targeted therapy, etc. However, since many cancers have lost the opportunity to be removed when they are discovered, the scope of application of surgery is very low; most chemotherapy drugs are not specific. Therefore, it will kill the normal tissue cells undergoing cell division at the same time, and the side effects are relatively high; the scope of radiation therapy is very narrow, and its effect can only be limited to the irradiated area; the efficacy of ta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K31/4375A61K31/7048A61K36/539A61K36/718A61K36/756A61P35/00
CPCA61K39/3955A61K31/7048A61K31/4375A61K36/718A61K36/539A61K36/756A61P35/00A61K2300/00
Inventor 王永华陈学通丁伯娇郭子湖
Owner HEZE UNIV
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