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Contact lens material comprising large molecular monomer of siloxanes structure on side chain

A macromonomer, contact lens technology, applied in glasses/goggles, instruments, optics, etc., can solve the problems of improving and hindering the mobility of siloxane structure, and can not expect oxygen permeability.

Inactive Publication Date: 2004-05-26
HOYA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the macromonomer of the structure developed in the prior art 2 has a siloxane structure on the main chain, and has a structure having functional groups at both ends, and thus, the two ends of the macromonomer in the polymer are connected to other components through Combination hinders the mobility of the siloxane structure, and a substantial improvement in oxygen permeability cannot actually be expected

Method used

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  • Contact lens material comprising large molecular monomer of siloxanes structure on side chain
  • Contact lens material comprising large molecular monomer of siloxanes structure on side chain
  • Contact lens material comprising large molecular monomer of siloxanes structure on side chain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Synthesis of macromonomer (A)

[0056] 8.88 g of isophorone diisocyanate, 0.025 g of dibutyltin dilaurate as a catalyst, and 45 mL of dichloromethane were added to the three-necked flask, and stirred under a nitrogen stream. Then, accurately weigh 20 g of α-butyl-ω-[3-(2,2-bis(hydroxymethyl)butoxy)propyl]polydimethylsiloxane, and add it dropwise to the flask in about 3 hours internal reaction. After reacting at room temperature for 48 hours, further accurately weighed 0.025 g of dibutyltin dilaurate and 23.3 g of polyethylene glycol-methacrylate, and added them dropwise to the flask in about 30 minutes. The mixture was covered with aluminum foil and stirred until the absorption band produced by isocyanate (2260cm -1 ) disappeared (reacted at room temperature for about 48 hours). After further adding dichloromethane to this solution, wash with a large amount of water, dehydrate, filter, and evaporate the solvent to obtain a macromonomer (A) having a structure shown in...

Embodiment 2～10

[0085] Except for changing the composition as shown in Table 1, the same procedure as in Example 1 was carried out to obtain contact lenses. However, Examples 8 to 10 used a diluent in combination as shown below. The obtained contact lens was excellent in flexibility and oxygen permeability. In addition, DMAA represents N,N-dimethylacrylamide, and HEMA represents 2-hydroxyethyl methacrylate.

Embodiment 8

[0087] To a glass sample bottle with a capacity of 30 mL, 5.1 g (25.5% by weight) of macromonomer (A) represented by formula (III), 6.8 g (34% by weight) of RAVINOL, 3.74 g (18.7% by weight) of DMAA, 1.36 g (6.8% by weight) of HEMA, 3 g (15% by weight) of 1-hexanol (hereinafter referred to as HeOH) as a diluent, and 0.085 g of AIBN (total of macromonomer (A), RAVINOL, DMAA, and HEMA The amount is 0.5% by weight), fully stirred, and the monomer mixed liquid is prepared. Then, it was carried out in the same manner as in Example 1 to obtain an ophthalmic lens. The obtained contact lenses were excellent in flexibility and oxygen permeability as shown in Table 1.

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Abstract

The invention provides a contact lens material and contact lens having excellent pliability and oxygen permeability. This contact lens material consists of a copolymer which is expressed by the following general formula (I) and consists of a siloxane macromer (A) component having a number average molecular weight of about 1,000 to 10,000, a water-insoluble monoolefinic monomer (B) component and a water-soluble monoolefinic monomer (C) component. This soft contact lens is formed by incorporating water into the copolymer which is expressed by the following general formula (I) and is obtained by pouring a monomer liquid mixture containing the siloxane macromer (A) component having the number average molecular weight of about 1,000 to 10,000, the water-insoluble monolefinic monomer (B) component and the water-soluble monoolefinic monomer (C) component into a mold of a contact lens shape and copolymerizing the liquid mixture.

Description

technical field [0001] The present invention relates to contact lens materials and soft contact lenses that are better biocompatibility and oxygen permeability polymers. The soft contact lens of the present invention has a moisture content of, for example, 15 to 35%, and is excellent in flexibility and oxygen permeability. Background technique [0002] According to clinical results, it has been pointed out that when contact lenses are worn, the oxygen supply from the atmosphere decreases, and the result may be related to the inhibition of corneal epithelial cell division or corneal hypertrophy. Therefore, in order to provide highly safe contact lenses, improvement of the oxygen permeability of raw materials has been attempted in the prior art. [0003] As for the improvement of oxygen permeability in hard contact lenses, there have been attempts to introduce silicone methacrylate, fluoroalkyl methacrylate, etc. into the raw material components. In this way, the oxygen perm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G02C7/04C08F283/12C08F290/06C08G18/61C08G18/67C08G77/26C08G77/42G02B1/04
CPCG02B1/043C08G18/61C08G18/6795C08F283/12C08F290/068C08L51/085C08G77/42
Inventor 今福元
Owner HOYA CORP