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Synthesis of oligosaccharide

A synthesis method and technology of oligosaccharides, applied in the direction of oligosaccharides, etc., can solve the problems of low yield, high price, and many steps in the synthesis of oligosaccharides

Inactive Publication Date: 2004-12-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The monomers used in the synthesis of oligosaccharides by the existing solid-phase carrier method are vinyl sugars, and the synthesis steps of vinyl sugars are many, the yield is low, and the price is expensive, which limits its application.

Method used

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  • Synthesis of oligosaccharide
  • Synthesis of oligosaccharide
  • Synthesis of oligosaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0053] Synthesis of vector

[0054] The raw material ratio is as follows

[0055] Styrene (chemically pure) 49.50 grams

[0056] Divinylbenzene (chemically pure) 0.5 g

[0057] Dibenzoyl peroxide (chemically pure) 2.5 grams

[0058] Xylene (analytical pure) 50 grams

[0059] Process:

[0060] Use a 500ml four-neck round bottom flask equipped with an electric stirrer, one of which is equipped with a spherical condenser (the upper end of the condenser is connected to the oil seal tube). One port is connected to the nitrogen cylinder, and the other port is equipped with a dropping funnel. Add 25g of xylene into the four-necked bottle, raise the temperature to 80±5°C, and add it dropwise for 1 to 2 hours under the condition of nitrogen protection. Dibenzoyl peroxide is dissolved in divinylbenzene, styrene and the remaining xylene After the dropwise addition of the mixed solution formed in the solution, keep it warm at 80±5°C for one hour, 100±5°C for two hours, cool down to ...

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Abstract

The present invention relates to the chemical synthesis of saccharide compound and is especially the synthesis of oligosaccharide. Saccharide monomer with glycosyl chain containing epoxy radical or capable of possessing formed epoxy radical is used as material and connected via coupling agent to carrier, on which the glycosyl chain extends via non-glycoside chain. he synthesized oligosaccharide is finally dissociated with ammonium salt from the carrier.The present invention synthesizes oligosaccharide with controllable saccharide untis via solid phase carrier process and expands the source of oligosaccharide.

Description

technical field [0001] The present invention relates to the chemical synthesis of carbohydrate compounds, especially the synthesis method of oligosaccharides. Background technique [0002] Polysaccharides widely exist in animals, plants and microorganisms. As one of the three major components of the life process, it is widely involved in the regulation of various life phenomena and physiological processes of cells, such as the transmission and feeling of information between immune cells, cell transformation, division and regeneration and other activities. In recent years, a large number of pharmacological and clinical studies have shown that polysaccharides are an immunomodulator, which can activate immune receptors and improve the immune function of the body. When used in the adjuvant therapy of cancer, it has less toxic and side effects and is safe. High, good anti-tumor effect and other advantages. [0003] Oligosaccharides are widely used in the treatment of cancer, AI...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H3/06C08B37/00
Inventor 李琳冯宗财陈玲郭祀远胡松青李冰王兆梅
Owner SOUTH CHINA UNIV OF TECH