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Application of kaempferol derivative in preparing medicine for cerebrovascular diseases

A technology of cerebrovascular disease and kaempferol, applied in the field of medicine, can solve the problems of unseen systemic pharmacology or drug efficacy, difficulty in preparing monomeric compounds, etc.

Inactive Publication Date: 2005-04-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

One of the reasons is that it is difficult to prepare a sufficient amount of monomeric compounds, so there are no reports on systematic pharmacology or drug effects.

Method used

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  • Application of kaempferol derivative in preparing medicine for cerebrovascular diseases
  • Application of kaempferol derivative in preparing medicine for cerebrovascular diseases

Examples

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Embodiment 1

[0016] Example 1: Preparation of kaempferol; 6-hydroxykaempferol; kaempferol-3-glucoside; kaempferol-3-rutinoside; 6-hydroxykaempferol-3-glucoside; 6-hydroxykaempferol-3,6 -Diglucoside; 6-hydroxykaempferol-3,6,7-triglucoside;

[0017] Take 30kg of Hefei safflower dry medicinal materials, soak each in 80% ethanol 100L at room temperature for 48 hours, extract three times, combine the extracts, and recover the ethanol under reduced pressure to obtain the concentrated solution; follow the usual sequence of extraction with petroleum ether, ether, and water-saturated n-butanol , The petroleum ether extraction part was discarded, and the ether and n-butanol extraction parts were concentrated under reduced pressure and then subjected to column chromatography one by one.

[0018] 1. The ether extract was subjected to silica gel column chromatography, and eluted with petroleum ether-ethyl acetate (30:1 to 1:1) and chloroform-methanol (10:1 to 1:1, the same below) solvent system as usual , ...

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Abstract

The invention relates to the technical field of medicine, and relates to the application of kaempferol and derivatives thereof in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases. The flowers and leaves of plants such as safflower, breviscapus, and ginkgo biloba have been used to prevent and treat cardiovascular and cerebrovascular diseases. They all contain kaempferol and its derivatives, but there are no reports on the use of these compounds to prepare drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases. Systematic pharmacology and efficacy tests of the present invention prove that kaempferol and its derivative monomers have the effect of preventing and treating cardiovascular and cerebrovascular diseases, so they can be used to prepare medicines for preventing and treating cardiovascular and cerebrovascular diseases.

Description

Technical field [0001] The invention relates to the technical field of medicine, and is the application of kaempferol and its derivatives in preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases. Background technique [0002] Safflower (Flos Carthami) is a commonly used traditional Chinese medicine, which has the effects of promoting blood circulation, clearing blood stasis and relieving pain. It has been clinically used for the prevention and treatment of cardiovascular and cerebrovascular diseases; breviscapine is used as a dry whole herb, and its preparation has been used for treatment Hypertension, cerebral thrombosis, cerebral hemorrhage, polyneuritis, chronic arachnoiditis and other cerebrovascular accidents caused by paralysis, coronary heart disease, angina pectoris and other diseases; and ginkgo has been made into ginkgo leaf capsules and other dosage forms for cardiovascular and cerebrovascular Disease prevention and treatment. Anal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/325A61K31/352A61P9/10
Inventor 郭美丽张戈
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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