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Method for applying polymer coating to internal surface of container

A kind of polymer coating and polymer technology, which is applied to the device, container, coating, etc. of the surface coating liquid, which can solve the problems of expensive application, drug pollution source, time-consuming, etc.

Inactive Publication Date: 2006-04-26
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such adhesives can be expensive and time-consuming to apply, and can also be a source of contamination of the drug product

Method used

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  • Method for applying polymer coating to internal surface of container
  • Method for applying polymer coating to internal surface of container
  • Method for applying polymer coating to internal surface of container

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0092] Take eight standard non-anodized aluminum cans and ten anodized aluminum cans and coat substantially the entire interior surface of the cans. The standard cans were applied two polymer coats at a time using an in-line spray gun spray pattern. The anodized cans were applied with a single polymer coating using an axial spray gun spray pattern.

[0093] The surface topography was obtained using a Microfocus Compact  Measurement system measurement. Measurements are made on the side wall of the tank. The coatings were sputtered with gold (VG Microtech Model SC7640 Sputter Coater) to improve surface reflectance prior to measurement. The measured area is 0.5 mm by 0.5 mm with a dot density of 100 dots / mm. Roughness coefficients for individual cans, as well as average, maximum and minimum roughness coefficients, for anodized and standard cans, are shown in Table 1.

[0094] Anodizing

tank number

Roughness (Ra)

standard

tank number

Roughn...

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PUM

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Abstract

Provided is a method for the application of a polymer coating to an internal surface of a container, which method comprises: (a) heating the inside surface of the container to be coated; (b) spraying an aqueous suspension of a fluorine-containing polymer onto the surface to form a coating on the surface; and (c) sintering the coating; wherein the container comprises a base and one or more side walls defining a container opening and is suitable for storing a medicament, and wherein the spraying step is conducted with a first spraying means configured to produce an axial spray pattern that is substantially conical about an axis perpendicular to the container base.

Description

technical field [0001] The present invention relates to a method for applying a polymer coating to the interior surface of a container, and to a container coated with a polymer according to the method of the invention. In particular, the present invention relates to a method of applying a polymeric coating to the inner surface of a container used to store a medicament to prevent contamination of the medicament and to prevent the medicament from sticking to the container. Background technique [0002] Fluoropolymers have been used for decades as protective coatings for a variety of articles. For example, polytetrafluoroethylene (PTFE) has been widely used as a non-stick coating for kitchen utensils, such as fryers, and tools, such as saws. Polytetrafluoroethylene and similar fluoropolymers have also been used as hydrophobic overcoats for protecting surfaces from moisture. [0003] In recent years, Teflon  (PTFE) and perfluoroethylene propylene have been used to coat the i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B05D5/08B65D25/14B05D1/02B05D3/02B05D7/22B05D7/24B65D81/24
CPCB05D3/0218B05D5/083B05D7/227
Inventor J·H·格勒格尔J·D·尼科尔J·M·韦格尔兹恩
Owner ASTRAZENECA AB
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