Compound, compositions and methods for preventing neurodegeneration in acute and chronic injuries in central nervous system

A technology of central nervous system and compounds, applied in the field of nervous system diseases
CN1267408CInactive Publication Date: 2006-08-02GNT PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GNT PHARMA
Publication Date
2006-08-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn2+, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn2+ neurotoxicity, and free radical neurotoxicity.
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Description

technical field

[0001] The present invention relates to novel salicylic acid compounds, compositions, and methods for preventing and preventing neurological diseases accompanied by neuronal death. technical background

[0002] Excitotoxicity and Brain Disease

[0003] Hyperactivation of ionotropic glutamate receptors sensitive to N-methyl-D-aspartate (NMDA receptors) causes neuronal death and is known to mediate a variety of neurological disorders [Choi , Neuron 1:623-634 (1988)]. Glutamate is an excitatory neurotransmitter, which accumulates in large quantities in the brain and is susceptible to hypoxic-ischemic damage, which activates ionized glutamate receptors, making them accessible to calcium and sodium ions Infiltration, followed by neuronal death [Choi and Rothman, Annu Rev Neurosci: 13: 171-182 (1990)]. NMDA receptor antagonists significantly reduced hypoglycemia, hypoxia, and hypoxic-ischemia induced by brain injury [Simon, Swan, Griffiths, and Meldrum. Science...

Claims

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