Unlock instant, AI-driven research and patent intelligence for your innovation.

Cyclophosphadenosine glucosamine infusion prepn., and its prepn. process

A technology of meglumine cyclic adenosine monophosphate and large infusion, which is applied in the fields of medical formulas, medical preparations containing active ingredients, cardiovascular system diseases, etc. Adenosine Phosphate Meglumine Content and Other Issues

Inactive Publication Date: 2006-09-20
湖南中启制药有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current legal method for determining the content of cyclic adenosine meglumine in MCA water injection cannot separate these ultraviolet impurities from the characteristic ultraviolet absorption of cyclic adenosine monophosphate, so the current method cannot accurately determine the content of cyclic adenosine monophosphate in MCA glucose infusion. amine content, so that the quality of the drug can not be effectively guaranteed and controlled in production, a new method suitable for the production of MCA glucose infusion is needed to accurately measure the content of meglumine cyclic adenosine monophosphate in MCA glucose infusion, and control the production of the product Efficient testing methods for quality

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cyclophosphadenosine glucosamine infusion prepn., and its prepn. process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 Cyclic adenosine monophosphate glucosamine glucose injection

[0017] Formula Meglumine Cyclophosphate 60mg

[0018] Glucose 5g

[0019] Add water for injection to 100ml

[0020] Put glucose into water for injection according to the prescription to make a 50-60% concentrated solution, stir and boil according to the above-mentioned process, add 0.3% (g / 100ml) activated carbon of the concentrated solution, after boiling, add 60 mg of the main drug after decarbonization , add water for injection to 80% of the total amount, adjust the pH to 6.2 with 1% sodium hydroxide, add water for injection to the full amount, fine filter until clarified, fill in a legal container such as 50ml or 100ml, seal, heat at 115°C Autoclave for 30 minutes. Finally, the content of meglumine cyclic adenosine monophosphate in the injection is detected according to the quantitative determination method of meglumine cyclic adenosine monophosphate in the glucose injection.

Embodiment 2

[0021] Example 2 Adenosine Cyclophosphate Glucosamine Glucose Injection

[0022] Formula Meglumine Cyclophosphate 60mg

[0023] Glucose 5g

[0024] Citric acid 1mol / L solution 0.2ml

[0025] 1% sodium hydroxide (or hydrochloric acid) appropriate amount (for pH adjustment)

[0026] Add water for injection to 100ml

[0027] Put glucose into water for injection according to the prescription to make a 50-60% concentrated solution. Stir and boil according to the process, add 0.3 g / 100 ml of activated carbon, boil, add 60 mg of the main drug and 0.2 ml of citric acid 1mol / L solution after decarbonization, adjust the pH to 5.0 with 1% sodium hydroxide, and add water for injection to The whole amount, finely filtered until clarified, filled in 50ml or 100ml legal containers, sealed, sterilized by autoclaving at 115°C for 30 minutes. Finally, the content of meglumine cyclic adenosine monophosphate in the injection is detected according to the quantitative determination method of m...

Embodiment 3

[0028] Example 3 Adenosine Cyclic Monophosphate Meglumine Sodium Chloride Injection (suitable for use by diabetic patients who are not suitable for using glucose)

[0029] Formula Meglumine Cyclophosphate 60mg

[0030] Sodium chloride 0.9g

[0031] Add water for injection to 100ml

[0032] Put sodium chloride into water for injection according to the prescription to make a 20-25% concentrated solution, stir and boil according to the process, add 0.3% activated carbon in the concentrated solution, add 60 mg of the main drug after boiling and decarbonization, and then add injection Make up to 80% of the total amount with water, adjust the pH to 6.1 with 1% sodium hydroxide (or hydrochloric acid), add water for injection to the full amount, fine filter until clarified, fill in a legal container such as 50ml or 100ml, seal, 115°C, Autoclave for 30 minutes.

[0033] 2. Influence of the isotonic medium on the stability of the main drug in the large infusion

[0034] A. The effec...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An isosmotic transfusion preparation of cyclic AMP glucoamine contains cyclic AMP glucoamine and isosmotic medium (glucose or sodium chloride). Its preparing process featuring its pH value range as key condition for stability, its preparation method, and a method for measuring the content of cyclic AMP glucoamine are also disclosed so that the cross infection in the application can be prevented.

Description

technical field [0001] The invention relates to a large infusion preparation of meglumine cyclic adenosine monophosphate and a preparation method thereof. Background technique [0002] Cyclophosphate meglumine (chemical name, Meglumine Cyclophosphate; English name, Meglumine Adenosine Cyclophosphate; MCA for short; previous names, Xinxianan and Meilexin) injection, is a non-cardiac glycoside Cardiotonic drugs are mainly used for the treatment of heart failure, myocarditis, sick sinus syndrome, coronary heart disease, cardiomyopathy, and adjuvant treatment of arrhythmia. In recent years, it has been widely used clinically because of its definite curative effect, unique effect and good safety performance. [0003] The currently clinically used meglumine cyclophosphate injection is a small water injection, the specification is 2ml: 30mg; the usual dosage is 60-180mg / day. Because the main drug has a strong effect and the osmotic pressure is too low, it cannot be directly used ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7076A61P9/04A61P9/06A61P9/10
Inventor 赵升皓赵琛
Owner 湖南中启制药有限公司