Implantation type local drug delivery device and three-dimensional printing preparation method thereof
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[0039] The invention provides a three-dimensional printing preparation method of an implantable drug delivery device, the steps of which are:
[0040] (1) According to the designed implantable drug delivery device structure, use computer-aided (CAD) to obtain the three-dimensional data model of the drug delivery device, and perform two-dimensional layered slices to obtain the profile data of each layer of the drug delivery device, and then Input these data into the computer control terminal of the 3D printer; initialize the computer control terminal of the 3D printer, move the workbench to the designated position, and prepare for the first layer of bonding.
[0041] (2) Transport the mixture powder of the carrier and the drug ingredient to the working platform, roll and lay a layer of powder by the spreading rod, and then the computer terminal controls the printing head on the 3D printer to be on the X-Y plane according to the numerical control code corresponding to the shape o...
Embodiment 1
[0050] Use a mortar to crush polylactic acid (molecular weight 100k / GPC), hydroxyapatite, and sodium chloride into powder and sieve. The particle size of polylactic acid powder is controlled within the range of Φ150 μm to 175 μm. Hydroxyapatite and chlorine The particle size of sodium chloride powder is controlled in the range of Φ100μm~150μm. Throw 20g of polylactic acid into the stirring container, then add 2g of hydroxyapatite and 3g of sodium chloride into the stirring container and stir well, then take out 15g for use (referred to as mixed powder A). Then add 10g of levofloxacin powder to the container and mix evenly (referred to as mixed powder B). Another 100ml of acetone, 10ml of ethanol, 10ml of distilled water and 0.5ml of glycerin were mixed in the container, and then 1g of polyvinylpyrrolidone and 1.5g of sodium lauryl sulfate were added to fully dissolve, and 80ml was measured and injected into the first print head. Add 10g of levofloxacin to the original contain...
Embodiment 2
[0053] Use a mortar to crush polyε-caprolactone (molecular weight: 60k / GPC) and sodium chloride into powder and sieve. The particle size of polyε-caprolactone powder is controlled within the range of Φ150μm~175μm. The powder particle size is controlled in the range of Φ100μm~150μm. Throw 20g of polyε-caprolactone into the stirring container, then add 3g of sodium chloride into the stirring container and stir well, then take out 12g for later use (referred to as mixed powder C). Then add 12g of fluorouracil powder into the container and mix well (referred to as mixed powder D). Another 100ml of chloroform, 15ml of ethanol, 10ml of distilled water, and 1ml of glycerin were mixed in a container, and then 2g of polyvinylpyrrolidone and 1g of sodium lauryl sulfate were added to fully dissolve, and 80ml was measured out and injected into the first print head. Add 12g of fluorouracil to the original container, dissolve it and inject it into the second printing head.
[0054]Clean t...
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