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Agents for intravitreal administration to treat or prevent disorders of the eye

A vitreous and reagent technology, applied in the field of medicaments and antimetabolites for the treatment or prevention of certain ophthalmic diseases, can solve problems such as retinal detachment or tear, blood vessel hemorrhage, danger, etc.

Inactive Publication Date: 2002-10-30
透明视网膜技术公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of vitreous extraction is very technical and is associated with several significant disadvantages, dangers, and complications
Among the disadvantages, risks and complications, the act of removing the vitreous may further cause detachment or tearing of the retina and / or such removal of the vitreous will further cause bleeding of already fragile blood vessels

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 8

[0071]Example 8 Urea USP / NF 4.0% Hyaluronidase 1.0IU-100IU Sodium Chloride USP / NF Up to 0.9% Sterile Water for Injection USP Q.S. The pH of 100% solution is 5.0-7.0 (PH uses 0.1N hydrochloric acid / 0.1 hydrogen Sodium oxide adjustment) Example 9 Urea USP / NF 0.01%-15.0% Hyaluronidase 1.0IU-100IU Sodium Chloride USP / NF Up to 0.9% Sterile Water for Injection USP Q.S. pH 5.0-7.0 of 100% solution (PH Adjust with 0.1N hydrochloric acid / 0.1N sodium hydroxide)

Embodiment 10

[0072] Example 10 Urea USP / NF 0.01%-15.0% Urokinase 1.0IU-50IU Sodium Chloride USP / NF Up to 0.9% Sterile Water for Injection USP Q.S. The pH of 100% solution is 5.0-7.0 (PH uses 0.1N hydrochloric acid / 0.1 N NaOH adjustment)

Embodiment 11

[0073] Example 11 Urea USP / NF 0.01%-15.0% Chondroitinase (Chondroitinase) ABC 1.0IU-30IU Sodium Chloride USP / NF Up to 0.9% Sterile Water for Injection USP Q.S. pH 5.0-7.0 of 100% solution (for pH 0.1N hydrochloric acid / 0.1 sodium hydroxide adjustment)

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PUM

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Abstract

Methods and preparations for treating disorders of the eye and / or causing posterior vitreous disconnection or disinsertion. Preparations containing (a) urea, (b) urea derivatives (e.g., hydroxyurea, thiourea), (c) a non-steroidal anti-inflamatory agent, (d) antimetabolites, (e) urea, urea derivatives, non-enzymatic proteins, nucleosides, nucleotides and their derivatives (e.g., adenine, adenosine, cytosine, cytadine, guanine, guanitadine, guanidinium, thymidine, thimitadine, uradine, uracil, cystine), uric acid, calcium acetal salicylate, ammonium sulfate or other compound capable of causing non-enzymatic dissolution of the hyaloid membrane or (e) any of the possible combinations thereof, are administered to the eye in therapeutically effective amounts.

Description

field of invention [0001] The present invention relates broadly to pharmaceutical preparations and methods of medical treatment, in particular agents (i.e. urea or urea derivatives, non-steroidal anti-inflammatory drugs (NSAIDS) and antimetabolites). Background of the invention [0002] A. Neovascularization [0003] Neovascularization (or angiogenesis) is the process by which new blood vessels are formed in body tissues. Normal neovascularization is the physiological process by which the body creates and maintains the small blood vessels of the circulatory system. However, pathological or iatrogenic neovascularization is the non-physiological process by which abnormal vascular networks are formed in body tissues or in tumors, leading to certain diseases, traumas or other surgical conditions. [0004] Pathological neovascularization in ocular tissue is the result of certain ophthalmic diseases, such as diabetic retinopathy, proliferative vitreoretino...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61K31/17A61K31/192A61K31/407A61K45/06
CPCA61K31/155A61K31/17A61K31/192A61K31/407A61K45/06A61P27/02A61P27/06A61P35/00
Inventor D·卡斯蒂莱约斯
Owner 透明视网膜技术公司
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