Engineered polypeptide resisting infection of coated virus (hepatitis B virus) and its preparing process

Abstract

An antivirus engineered polypeptide is composed of the polypeptide able to specifically bind coated virus antigen or receptor and the colicin able to form ion channel or its channel structure domain. It has two molecular structures divided according to different links between amino terminal and carboxyl terminal. Different engineered polypeptides for different viruses can be prepared by binding the colicin or its channel structure domain with the above-mentioned different polypeptide. Its advantage is sure effect on killing viruses.

Description

1. Technical field

[0001] The present invention relates to an artificially combined antiviral engineering polypeptide and a preparation method thereof, by preparing an engineered polypeptide (Engineered Polypeptide) composed of different bacterial toxins and polypeptides that can specifically bind to viral envelope antigens or receptors, such as scFv domains peptide) to achieve antiviral purposes. 2. Background technology

[0002] Viral infection has become a major threat to human life and health. As the earth's biosphere is increasingly destroyed by human industrialization, viral diseases, such as viral hepatitis, influenza, pneumonia, encephalitis, tumors caused by viruses, and AIDS, are becoming more and more rampant. Because the genes of viruses are prone to mutations, the damage caused by viruses is often involved in the malfunction of the host immune system. The mechanism is still being explored, so people have been working hard to try to prepare truly effective antivi...