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Biodegradable microcapsulated ultrasonic contrast medium and its prepn process

A biodegradable, ultrasonic contrast agent technology, applied in MRI/MRI contrast agents, drug delivery, emulsion delivery, etc., can solve the problems of small harmonic enhancement multiples, troublesome clinical application, and increase the cost of diagnosis.

Inactive Publication Date: 2003-02-26
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Although the above ultrasound contrast agents have their own characteristics, their common disadvantages are the short residence time of the bubbles and the small harmonic enhancement multiple. It has caused troubles to clinical application and increased the cost of diagnosis
Therefore, there is no satisfactory ultrasound contrast agent available for clinical application so far, and research on new ultrasound contrast agents with better efficacy and longer survival has become a hot spot in ultrasound contrast research.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] At 15°C, a dichloromethane solution of 5 mg distilled water and 200 mg polylactide (PLA) with a molecular weight of 10,000 was ultrasonically emulsified for 1 minute in the presence of Span 80 to form a water-in-oil emulsion. Inject 100 ml of 1% gelatin solution in the presence of Tween 80 and emulsify for 1 minute. The resulting water-in-oil-in-water emulsion. After stirring at 1000 rpm for 5 hours, the obtained microcapsules were separated by centrifugation. Washing with distilled water for four times, finally dispersing in water, freeze-drying to obtain a microcapsule type polylactide ultrasonic contrast agent with a particle diameter of 2-8 microns and a thickness of a capsule wall of 100 nanometers.

[0042] Dogs were used as simulated animals, and the ultrasound imaging effect in vivo was measured by intravenous infusion. The results showed that PLA microcapsules had more obvious imaging effects than the commercially available ultrasound contrast agents NF FC and...

Embodiment 2

[0045] At 20°C, a dichloromethane solution of 5 mg of distilled water and 200 mg of poly(lactide-co-glycolide) (PLGA) with a molecular weight of 10,000 was ultrasonically emulsified in the presence of Span 60 for 1 min to form a water-in-oil emulsion. At a stirring speed of 15,000 rpm, inject 100 ml of 1% gelatin solution in the presence of Tween 60, and emulsify for 1 minute. Add 300ml of distilled water (dichloromethane saturated), stir for 30 minutes, and obtain microcapsules by centrifugation. Washing with distilled water three times, finally dispersing in water, freeze-drying to obtain microcapsule type poly(lactide-glycolide) copolymer ultrasonic contrast agent with particle diameter of 6-12 microns and capsule wall thickness of 100 nanometers.

[0046] Effect of microencapsulated poly(lactide-glycolide) copolymer ultrasound contrast agent on ultrasound imaging and

[0047] Example 1 is similar.

Embodiment 3

[0049] A solution of 3 mg distilled water and 200 mg poly(lactide-caprolactone) copolymer (PLC) with a molecular weight of 150,000 in dichloromethane was ultrasonically emulsified in the presence of Span 60 for 90 seconds at 18° C. to form a water-in-oil emulsion. Inject 100 ml of 5% polyvinyl alcohol solution at a stirring speed of 5000 rpm, and emulsify for 5 minutes. The obtained water-in-oil-in-water emulsion was stirred at 1000 rpm for 3 hours, and the obtained microcapsules were separated by centrifugation. Washing with distilled water three times, dispersing in water, freeze-drying to obtain a microcapsule type poly(lactide-caprolactone) copolymer ultrasonic contrast agent with a particle diameter of 6-12 microns and a capsule wall thickness of 100 nanometers.

[0050] The Ratio of Ultrasonic Development Effect of Microencapsulated Poly(lactide-caprolactone) Copolymer Ultrasound Contrast Agent

[0051] Example 1 is better.

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PUM

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Abstract

The biodegradable microcapsulated ultrasonic contrast medium is a hollow microcapsule with size of 1-10 microns and wall thickness of 50-6000 nm. The preparation process includes the steps of: dissolving biodegradable fatty polylactone with organic solvent to compound solution A; adding emulsifier into distilled water to compound solution B; injecting solution B into solution A via supersonic emulsifying; adding the emulsion into water solution of stabilizer via stirring; stirring for 2-10 hr to separate microcapsules particle and washing with distilled water; and freeze drying the particle to obtain powdered biodegradable microcapsule. Via intravenous injection or intravenous dripping, the present invention may be made to enter myocardial microcirculation via left cardiac chamber and coronary artery for supersonic radiographic examination.

Description

technical field [0001] The invention relates to a microcapsule ultrasonic contrast agent. [0002] The present invention also relates to a preparation method of the above-mentioned contrast agent. Background technique [0003] Ultrasonic diagnostic technology is a technology that uses the difference in strength of reflected and scattered signals of ultrasonic waves at the interface of human tissues to transmit biological internal information, so as to achieve the purpose of diagnosis. Ultrasonic diagnosis has the advantages of safety, wide adaptability, intuition, repeated inspection, strong identification of soft tissue, strong flexibility and low price, so it has become the preferred technology in contemporary medical image diagnosis, and has been used in modern diagnostic technology. Occupying an extremely important position, conventional B-ultrasound examination has become an effective diagnostic method for most space-occupying lesions. However, due to the fact that th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61K49/18
Inventor 王身国智光崔文瑾徐勇贝建中赵玉英
Owner INST OF CHEM CHINESE ACAD OF SCI
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