Medicine for treating cardiovascular diseases and its preparing method

A cardiovascular and disease technology, applied in the field of preparation of the medicine, can solve the problems of cardiovascular disease and the like without the total alkaloids of lotus seed heart, and achieve the effects of inhibiting platelet aggregation, definite curative effect and inhibiting thrombosis.

Inactive Publication Date: 2003-10-01
吴梅春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medicine for the treatment of cardiovascular diseases with the total alkaloids of lotus seed heart

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Get 13.3 kg of lotus seed heart, reflux extraction with 75% ethanol twice, each time add 8 times the amount of 75% ethanol, reflux extraction for 1 hour, filter, combine the filtrates, recover the ethanol under reduced pressure and concentrate to a relative density of 1.07 (60°C ), adjust the pH to 2.5 with dilute hydrochloric acid, let stand, centrifuge, adjust the pH to 10 with 40% NaOH solution for the centrifugate, let stand, filter, take the precipitate, add 5 times the amount of ethanol to dissolve, let stand, filter, and the filtrate reduces The ethanol was recovered under pressure, concentrated to a relative density of 1.28 (60° C.), dried under reduced pressure, and pulverized to obtain the lotus seed heart extract. Take the above lotus seed heart extract, add 92 g of starch, mix well, and granulate with 75% ethanol, 60 ℃ drying, granulation with 16 mesh sieves, adding 1.2% magnesium stearate, mixing, tabletting, promptly made the tablet of the present invention...

Embodiment 2

[0018] Get 12.9 kg of lotus seed heart, reflux extraction with 80% ethanol twice, add 6 times of 80% ethanol each time, reflux extraction for 1 hour, filter, combine filtrates, recover ethanol under reduced pressure and concentrate to a relative density of 1.05 (60°C ), adjust the pH to 3.5 with dilute hydrochloric acid, let stand, centrifuge, adjust the pH to 10 with 40% NaOH solution in the centrifugate, let stand, filter, take the precipitate, add 4 times the amount of ethanol to heat and dissolve, let stand, filter, and the filtrate reduces Recover ethanol under pressure, concentrate to a relative density of 1.25 (60°C), dry under reduced pressure, and pulverize to obtain lotus seed heart extract, add 100 g of starch to mix evenly, granulate with 70% ethanol, and dry at 60°C , granulate with 16 mesh sieves, add 1% magnesium stearate, mix evenly, pack capsule, promptly make the capsule of the present invention, wherein the weight content of liensinine is 3.95%, the weight co...

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PUM

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Abstract

A Chinese medicine for treating cardiovascular dieases, such as myocardial ischemia, arrhythmia, thrombocyte coagulation and thrombosis, contains liensinine (1-10 wt.%) and common alkaloid of lotus (7-50 wt.%). Its preparing process is also disclosed.

Description

Technical field [0001] The invention relates to a medicine for treating cardiovascular diseases, in particular to a Chinese patent medicine prepared from the traditional Chinese medicine lotus seed heart, and also relates to a preparation method of the medicine. Background technique [0002] Lianzixin is the dry young leaves and radicles of the mature seeds of the water lily family plant lotus (Nelumbo nucifera Gaertn). It is a commonly used traditional Chinese medicine, which is recorded in the 2000 edition of "Chinese Pharmacopoeia". The results of modern medical and phytochemical studies have shown that lotus seeds contain a variety of alkaloids such as liensinine, neferine, ioliensinine, nuciferine, pronuciferine ( pronuciferine), etc. These alkaloids are the main active ingredients of lotus seed heart, called the total alkaloids of lotus seed heart, which have various cardiovascular pharmacological effects such as lowering blood pressure, anti-arrhythmia, and inhibitin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4725A61P9/10
Inventor 吴梅春
Owner 吴梅春
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