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Combination object of half solid framework preparation of gingko leaf extract product

A semi-solid and composite technology, applied in the field of ginkgo biloba extract preparations, to achieve the effects of improving hemorheology, reducing the degree of thrombus, and reducing the size of myocardial infarction

Inactive Publication Date: 2003-10-08
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is to disclose a semi-solid matrix preparation (Semi Solid Matrix) of Ginkgo biloba extract, that is, adding a substance with a waxy melting point to the medicinal liquid, which can be melted at high temperature and is Solid, compared with the traditional powder particle filling, it can avoid the flying of drug powder (especially for hormones and anticancer drugs); the filling amount is uniform, the main drug dosage is accurate; the drug or liquid is dispersed in the excipient and the air and Moisture is isolated, so it is more stable; proper adjustment of the prescription can obtain the expected high bioavailability, so as to make the pharmacologically active substances absorb better in the body, achieve good curative effect at a lower dose and reduce adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Mix 2 grams of Ginkgo biloba extract, 25 grams of polyoxyethylene castor oil diglyceride, and 73 grams of poloxamer, stir evenly, heat and dissolve, and make 100 capsules with a capsule liquid filling machine. The content of Ginkgo biloba extract is 0.02 g / capsule.

Embodiment 2

[0031] Mix 3 grams of Ginkgo biloba extract, 24 grams of polyoxyethylene castor oil and capric laurin mixture (1:1, weight ratio), and 73 grams of poloxamer, stir well, heat to dissolve, and fill with capsule liquid Machine-made into 100 capsules, the content of ginkgo leaf extract is 0.03 g / capsule.

Embodiment 3

[0033] 3 grams of Ginkgo biloba extract, 24 grams of polyoxyethylene 6 sorbitan monolaurate, and 73 grams of a mixture of polyoxyethylene 40 stearate and poloxamer (1:1, weight ratio) were mixed, Stir evenly, heat to dissolve, and make 100 capsules with a capsule liquid filling machine, and the content of ginkgo leaf extract is 0.03 g / capsule.

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PUM

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Abstract

A semi-solid skeleton composition of ginkgo leaf extract for treating coronary heart disease, angina pectoris, hyperlipemia and cerebrovascular disease, and preventing sanile dementia and cancer contains the ginkgo leaf extract (2-20 wt.%), surfactant (1-45 wt.%) and semi-solid skeleton carrier (40-92 wt.%). Its advantages are high biologic utilization rate and low dosage.

Description

technical field [0001] The invention relates to a ginkgo leaf extract preparation. Background technique [0002] Ginkgo biloba leaf extract, whose English name is Ginkgo bilola leaf extract, is an effective active ingredient extracted from Ginkgo biloba 1. As the origin of ginkgo, China has more than 70% of all ginkgo resources in the world. As early as 4,000 years ago, "Shen Nong's Materia Medica" recorded the medicinal value of ginkgo nuts. Modern medical research on Ginkgo biloba was first discovered by German scientist W. Sehwabe in the 1960s and affirmed the medical value of Ginkgo biloba. Subsequently, medical scientists from all over the world conducted more comprehensive and in-depth research on Ginkgo biloba. The main functions of comprehensive Ginkgo biloba products include: increasing cerebrovascular resistance and improving cerebrovascular circulation; Arteries, prevent angina pectoris and myocardial infarction; inhibit platelet aggregation, prevent thrombosis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K47/10A61K47/14A61K47/22A61K47/26A61K47/44A61P9/06A61P9/10A61P25/28A61P35/00
Inventor 顾林金沈航孝
Owner SHANGHAI INST OF PHARMA IND
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