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Thiophanate methyl inclusion complex pesticide preparation

A technology for thiophazine-methyl and pesticide preparations, which is applied in the field of pesticide chemistry, and can solve the problems of unfound literature data of thiophazine-methyl cyclodextrin inclusion compound preparations, etc.

Inactive Publication Date: 2003-10-15
西安敬业生物药物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] According to the retrieval, no literatures about the preparation of thiophazine-methyl cyclodextrin inclusion complex were found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1. Preparation of thiophanate-methyl cyclodextrin complex water and powder.

[0013] 1.1) Weigh 100g of thiophanate-methyl, add 196ml of acetone to make it fully dissolved; take another 500g of hydroxypropyl-β-cyclodextrin, add 1 liter of water to dissolve; The solution was added, and the stirring was continued for 3 hours to obtain an aqueous solution of the pesticide inclusion compound. The solution is dried and dusted to obtain a powder.

[0014] 1.2) Weigh 100g of thiophanate-methyl, add 350ml of ethanol to fully dissolve it; take another 800g of dimethyl-β-cyclodextrin, add 2 liters of water to dissolve it; , and continue to stir for 2 hours to obtain a drug complex aqueous solution. The solution is dried by a powder spraying machine to obtain a powder.

[0015] 1.3) Weigh 98g of thiophanate-methyl and fully dissolve it with 200ml of acetone; take another 200g of γ-cyclodextrin and dissolve it with 800ml of water; after mixing the two, homogenize for ...

Embodiment 2

[0016] Example 2. Preparation of thiophanate-methyl cyclodextrin inclusion complex emulsion and its powder.

[0017] 2.1) Weigh 68g of thiophanate-methyl, add 800ml of water, add 1000g of "polyethylene glycol 600" and stir and emulsify for 1 hour to make an emulsion; take another 200g of β-cyclodextrin, add 1 liter of water to dissolve, and stir at 60°C. Add the thiophanate-methyl emulsion and continue to stir for 3 hours to obtain a stable emulsion of pesticide inclusions. The liquid can be dried by a powder spraying machine to obtain a powder.

[0018] 2.2) Weigh 30g of thiophanate-methyl, add 500ml of water, add 60g of "polyethylene glycol 2000" and stir and emulsify for 1 hour to make an emulsion, and take another 290g of mixed cyclodextrin (containing α-, β- and γ-cyclodextrin 50%, containing 50% of maltodextrin in addition) add 1 liter of water to dissolve, under the stirring condition of 50 ℃, add thiophanate-methyl emulsion, continue to stir for 2 hours, then add 2g ...

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PUM

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Abstract

The farm chemical preparation of thiophanate-methyl clatherate features that thiophanate-methyl molecules are included inside cyclodextrin with cyclic molecular structure. The said cyclodextrin may be any one kind of cyclodextrins or derivatives or their mixture. Cylcodextrin has many hydroxyl groups distributed in the outer part and thus high hydrophilicity and water solability, so that including water insoluble thiophanate-methyl with cyclodextrin can raise the water solability, stabilization, emulsifying capacity and germicidal effect of the farm chemical.

Description

technical field [0001] The invention belongs to the technical field of pesticide chemistry, in particular to the improvement of thiophanate-methyl pesticide preparation. Background technique [0002] Thiophanate-methyl is a commonly used low-toxicity agricultural fungicide, which belongs to broad-spectrum systemic fungicide; Fungal diseases of crops, oil, flowers and other crops. The substance is insoluble in water, easily soluble in acetone, formaldehyde, chloroform, soluble in methanol, ethanol and other solvents. Most of the currently commercially available products are 70% wettable powders or dry powders and colloidal suspensions added with auxiliary materials. When in use, they cannot be directly dissolved in water, which leads to more use of powder spraying. In this way, the amount of drug application increases, the crops are not easy to absorb, and the utilization efficiency is low. In addition, the exposure of drug molecules will easily affect its chemical stabilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N47/28
Inventor 郝英俊谢伯泰
Owner 西安敬业生物药物科技有限公司
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