Drug-eluting stent (DES) with multicoating

A multi-layer coating and eluting stent technology, applied in the field of medical devices, to achieve the effect of no cracking, disease prevention, and uniform distribution

Inactive Publication Date: 2004-01-07
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to further optimize and improve on the basis of Chinese patent applicatio

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034] Example 1

[0035] Add 0.2g polybutyl methacrylate to 10ml N,N-dimethylformamide, mix and disperse uniformly, then add 0.1g rapamycin (Rapamycin), disperse uniformly at room temperature, and then spray on the surface of the stent, medium flow 0.2ml / min, spraying time 60 seconds, and then put the stent in a vacuum oven at 40°C and dry for 24 hours.

[0036] Add 1g of gelatin protein to 99ml of water and disperse evenly at 37°C. Add 0.5g of heparin sodium to disperse evenly. Take the stent and soak in the dispersion for 30 seconds, take it out and dry it under reduced pressure at room temperature for 10 hours, and then use 30°C. Formaldehyde steam crosslinking for 10 minutes.

Example Embodiment

[0037] Example 2

[0038] Add 0.3g lactide-ε-caprolactone copolymer to 5ml chloroform, mix and disperse uniformly, then add 0.1g actinomycin-D, disperse uniformly at room temperature, and then immerse the stent in the dispersion for 1-30 minutes. The stent was then taken out and cured in a vacuum oven at 60°C for 2 hours.

[0039] Add 1g of gelatin protein to 99ml of water and disperse evenly at 37°C, then add 0.5g of tirofiban to disperse evenly, and apply spraying method to the outer surface of the stent. The medium flow rate is 0.5ml / min, and the spraying time is 100 seconds. After taking it out, it was dried under reduced pressure at room temperature for 10 hours, immersed in 37% formaldehyde solution, and cross-linked for 10 hours.

Example Embodiment

[0040] Example 3

[0041]Add 0.2g of polymethyl lactone to 10ml of N,N-dimethylformamide, mix and disperse evenly, then add 0.1g of FTY720, disperse evenly at room temperature, and spray on the surface of the stent. The medium flow rate is 0.5ml / min. The spray time is 100 seconds. Then put the stent in a vacuum oven at 40°C for curing for 24 hours, and the stent is ready for use.

[0042] Add 1g of polyvinyl alcohol to 99ml of water, after uniformly dispersed at 50°C, add 0.5g of heparin sodium to disperse evenly, take the stent and soak in the dispersion for 30 seconds, take it out, and dry it in a vacuum oven at 40°C for 10 hours.

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PUM

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Abstract

The present invention discloses a Drug-eluting stent (DES) with multiple coating layer, its preparation method and application. Said stent consisting stent and coating layer convered on the stent surface. It is characterized by that the surface of the stent has 1-4 layers of coating layers, in which at least two layers are medicine-carried layer, and said medicine-carried layer is composed of (wt%) 0.5-99% of polymer, 0-10% of additive and 0.5-99% of active component, and between the medicine-carried layer and stent a base layer can be set so as to raise the anchoring force of medicine-carried layer and stent, and the surface of medicine-carried layer also can be more coated with a surface layer.

Description

[0001] technical field [0002] The invention relates to the field of medical devices, in particular to a drug-eluting stent with a multi-layer coating. Background technique [0003] Arterial stents are the main means of interventional therapy for cardiovascular and peripheral vascular occlusive lesions. Since Sigwart et al. placed the first case of coronary artery stents (PTCA stents) in the human body in 1986, the application and popularization of this technology has been rapid, and it has now accounted for the More than 80% of diseases are treated. [0004] But at the same time, the biggest disadvantage of this technology is the occurrence of restenosis after stents, and the incidence of restenosis after stents is currently about 20%. The cause of stent restenosis is that blood vessels are damaged by stent expansion, which induces excessive proliferation of vascular smooth muscle cells (VSMCs) and migrates to the intima, eventually leading to vascular restenosis. [0005]...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61M29/00A61M31/00
Inventor 张一唐智荣高润霖
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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