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Drug-eluting stent (DES) with multicoating

A multi-layer coating and eluting stent technology, applied in the field of medical devices, to achieve the effect of no cracking, disease prevention, and uniform distribution

Inactive Publication Date: 2004-01-07
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to further optimize and improve on the basis of Chinese patent application 02112242.3, to provide a stent with a more uniform, firm coating, no cracking and peeling, and can prevent various postoperative complications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Add 0.2g polybutylmethacrylate to 10ml N,N-dimethylformamide, mix and disperse evenly, then add 0.1g rapamycin (Rapamycin), disperse evenly at room temperature, then spray on the surface of the stent, medium flow 0.2ml / min, spray time 60 seconds, then place the bracket in a vacuum oven at 40°C and dry for 24 hours.

[0036] Add 1g of gelatin protein to 99ml of water, disperse evenly at 37°C, add 0.5g heparin sodium to disperse evenly, take the above-mentioned scaffold and dip it in the dispersion liquid for 30 seconds, take it out and dry it under reduced pressure at room temperature for 10 hours, and then dry it at 30°C Formaldehyde vapor crosslinked for 10 minutes.

Embodiment 2

[0038] Add 0.3g lactide-ε-caprolactone copolymer to 5ml chloroform, mix and disperse evenly, then add 0.1g actinomycin-D, disperse evenly at room temperature, then immerse the scaffold in the dispersion for 1-30 minutes, The stent was then taken out and cured in a vacuum oven at 60° C. for 2 hours.

[0039] Add 1g of gelatin protein to 99ml of water, disperse evenly at 37°C, add 0.5g of tirofiban to disperse evenly, and apply it on the outer surface of the stent by spraying, the medium flow rate is 0.5ml / min, and the spraying time is 100 seconds. After taking it out, it was dried under reduced pressure at normal temperature for 10 hours, immersed in 37% formaldehyde solution, and cross-linked for 10 hours.

Embodiment 3

[0041]Add 0.2g polymethyl acrylate to 10ml N,N-dimethylformamide, mix and disperse evenly, then add 0.1g FTY720, disperse evenly at room temperature, spray on the surface of the stent, the medium flow rate is 0.5ml / min, The spray time is 100 seconds. Then place the bracket in a vacuum oven at 40° C., cure for 24 hours, and the bracket is ready for use.

[0042] Add 1g of polyvinyl alcohol to 99ml of water and disperse evenly at 50°C, then add 0.5g of heparin sodium to disperse evenly, take the above scaffold and dip it in the dispersion for 30 seconds, take it out and dry it in a vacuum oven at 40°C for 10 hours.

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PUM

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Abstract

The present invention discloses a Drug-eluting stent (DES) with multiple coating layer, its preparation method and application. Said stent consisting stent and coating layer convered on the stent surface. It is characterized by that the surface of the stent has 1-4 layers of coating layers, in which at least two layers are medicine-carried layer, and said medicine-carried layer is composed of (wt%) 0.5-99% of polymer, 0-10% of additive and 0.5-99% of active component, and between the medicine-carried layer and stent a base layer can be set so as to raise the anchoring force of medicine-carried layer and stent, and the surface of medicine-carried layer also can be more coated with a surface layer.

Description

[0001] technical field [0002] The invention relates to the field of medical devices, in particular to a drug-eluting stent with a multi-layer coating. Background technique [0003] Arterial stents are the main means of interventional therapy for cardiovascular and peripheral vascular occlusive lesions. Since Sigwart et al. placed the first case of coronary artery stents (PTCA stents) in the human body in 1986, the application and popularization of this technology has been rapid, and it has now accounted for the More than 80% of diseases are treated. [0004] But at the same time, the biggest disadvantage of this technology is the occurrence of restenosis after stents, and the incidence of restenosis after stents is currently about 20%. The cause of stent restenosis is that blood vessels are damaged by stent expansion, which induces excessive proliferation of vascular smooth muscle cells (VSMCs) and migrates to the intima, eventually leading to vascular restenosis. [0005]...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61M29/00A61M31/00
Inventor 张一唐智荣高润霖
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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