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Preparing method for high-purity lycopene

A lycopene, high-purity technology, applied in the field of separation engineering, can solve the problems of expensive chromatographic equipment, high production cost, difficult liquid separation and separation, etc., and achieve the effect of simple process operation, low cost and high purity

Inactive Publication Date: 2004-02-04
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent (publication number: 1405234) has reported a method for purifying lycopene with reverse phase chromatography, and the resulting product purity is as high as more than 99%, but these purification methods require expensive chromatographic equipment, low production efficiency, high production cost, and no Suitable for industrial production
The disadvantage of this method is that a large amount of foam will be formed after the saponification reaction, and the fine crystals of lycopene freed from the oil will be wrapped by the foam, making it difficult to separate the liquid. In addition, lycopene is easy to dissolve in alkaline solution. go bad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 10 grams of lycopene oleoresin with a content of 6.0%, add 200mL of n-hexane solvent and stir at 40°C for 1 hour under nitrogen protection to form a saturated solution, then hot filter, and the filtrate is cooled and crystallized in an environment of 0°C. Hours, lycopene crystallized out. Dark red lycopene crystals were obtained by filtration, with a purity of 99.2%, a yield of 18.2%, and a melting point of 173-175°C.

Embodiment 2

[0015] Weigh 15 grams of lycopene oleoresin with a content of 12.0%, add 400mL of n-hexane solvent and stir at 60°C for 0.5 hours under nitrogen protection to form a saturated solution, then heat filter to remove impurities, and place the filtrate in an environment of -5°C After cooling and crystallizing for 1 hour, lycopene crystals were precipitated. The dark red lycopene crystals were obtained by filtration, with a purity of 98.0%, a yield of 24.3%, and a melting point of 173-175°C.

Embodiment 3

[0017] Weigh 10 grams of lycopene oleoresin with a content of 6.0%, add 200mL of n-hexane solvent, stir and dissolve at 70°C under nitrogen protection to form a saturated solution, then heat filter to remove impurities, and place the filtrate in an environment of -10°C Cool and crystallize for 0.5 hour, filter to obtain dark red lycopene crystals with a purity of 95.6%, a yield of 40.1%, and a melting point of 173-175°C.

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Abstract

A process for preparing high-purity licopin includes such steps as dissolving the licopin oil resin in organic hydrocarbon solvent to obtain saturated solution at higher temp under protection of inertial gas, hot filtering, low-temp cooling while crystallizing, and filtering.

Description

Technical field: [0001] The invention relates to a preparation method of high-purity lycopene, which uses lycopene oleoresin as a raw material, adopts an organic solvent and combines a low-temperature crystallization method to improve the purity of lycopene, and belongs to the technical field of separation engineering. Background technique: [0002] Lycopene is a carotenoid that mainly exists in nature, such as in common fruits such as tomato, watermelon and guava. Research in the past 20 years has shown that lycopene has a strong antioxidant capacity, and its efficiency in scavenging singlet oxygen is twice that of β-carotene and 50 times that of vitamin E. It can prevent and treat prostate cancer, lung cancer, and cardiovascular diseases. , Physiological functions such as delaying aging, regulating intercellular communication and activating immune cells. With the discovery of superior physiological functions of lycopene, its application prospects in the field of medicine ...

Claims

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Application Information

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IPC IPC(8): C07C7/14C07C11/02
Inventor 赵亚平于文利王大璞
Owner SHANGHAI JIAO TONG UNIV
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