Polyacrylic acid film forming compsn.
A composition, polymer technology, applied in the production of this dosage form, non-gel-forming film-forming coating weight, increased water solubility on dip-coated tablets or caplets, capable of addressing gloss loss, surface roughness, encapsulation Clothes look unsatisfactory, etc.
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Embodiment 1
[0072] Embodiment 1) prepare dip-coating dispersion liquid
[0073] Aqueous dispersions containing the ingredients listed in Table A were prepared.
[0074] Element
Weight (g)
Available from Rohm Pharma under the trade name "Eudragit RL30D"
Poly(ethyl acrylate, methyl methacrylate), methyl propylene chloride
Trimethylaminoethyl enoate (30% solution) *
100.0
Methylparaben
5.0
Bought from BASF Aktiengesellschaft under the trade name "K-90"
polyvinylpyrrolidone
12.0
water
60.0
Red#55 dye
1.0
Red#40 Lake
0.5
PEG400
4.0
total solution weight
182.5
solids in paint solution
52.5g(28.78%)
[0075] Element
Weight (g)
Available from Rohm Pharma under the trade name "Eudragit RL30D"
Poly(ethyl acrylate, methyl methacrylate), methyl propylene chloride
Trimethylaminoethyl enoate (30% solution) ...
Embodiment 2
[0078] Embodiment 2) preparation secondary coating dispersion liquid
[0079] An aqueous dispersion containing the ingredients listed in Table C was prepared by mixing all ingredients in a beaker under ambient conditions.
[0080] Element
Embodiment 3
[0081] Embodiment 3) prepare dip-coated tablet
[0082] Compressed tablets were prepared according to the method set forth in Example 1 of US Patent No. 5,658,589 ("the '589 patent"), which is incorporated herein by reference.
[0083] The subcoat dispersion of Example 2 was then applied to the above-mentioned tablets by spraying according to the procedure given in the examples of the '589 patent. The weight of the dry tablet with the subcoat was about 4.5% greater than the tablet without the subcoat, ie the amount of the subcoat was about 4.5% of the weight of the uncoated core.
[0084]Half of each of these subcoated tablets was manually dipped into the first dip coating dispersion of Example 1 for a dwell time of 1 second, removed from the dip coating solution, and reapplied under ambient conditions. dry. This process was repeated for each tablet; the other half of each coated tablet was dip-coated in the second dip-coating dispersion of Example 1. The weight gains of th...
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