Chinese medicine compound preparation and its preparation process

A technology for compound preparations and traditional Chinese medicines, which can be used in pharmaceutical formulations, antifungal agents, drug combinations, etc., and can solve problems such as reduced efficacy

Inactive Publication Date: 2004-10-13
浙江南洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For this reason, Zhejiang Kelisi'an Pharmaceutical Co., Ltd. has developed a new dosage form - Fuyanling Effervescent Tablets, which has the advantages of fast drug dissolution, and increases and prolongs the contact area between the drug and the folds of the vaginal and cervical mucous membrane at the same time as the foam is produced. Advantages such as time and time, overcome the discomfort caused by capsules, and the disadvantages of curative effect reduction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1: Optimal preparation process of Fuyanling effervescent tablets

[0010] Prescription: Sophora flavescens 100g Cnidium 100g Purple pearl leaves 100g

[0011] Agrimony 100g Baibu 100g Boric acid 60g Benzalkonium bromide 6g

[0012] borneol 5g camphor 10g alum 10g

[0013] Preparation process: take Sophora flavescens and Fructus Cnidii according to the prescription, crush them into coarse powder, heat and reflux extraction twice with 14 times of 85% ethanol, each time for 1 hour, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to relative density 1.10-1.18 (50°C), add 30g of starch, mix well, and dry at 60°C for later use. Add 12 times the amount of water to decoct twice, 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.20-1.30 (50 ℃), add 10g of starch and mix well, and dry at 80°C for later use; 60g of boric acid, 90g of citric acid and 70g of sodium bicarbona...

Embodiment 2

[0014] Example Two Fuyanling Effervescent Tablets Disintegration Time Limit Test

[0015] 1. Instrument: lifting disintegration instrument

[0016] 2. Test method: according to the disintegration time limit inspection method of Appendix XIIA of the Pharmacopoeia of the People's Republic of China

[0017] 3. Test drugs: 6 tablets of this product; 6 Fuyanling capsules.

[0018] serial number

[0019] 5. Conclusion: The disintegration time of Fuyanling effervescent tablets does not exceed 3 minutes, while the disintegration time of Fuyanling capsules exceeds 16 minutes. Fuyanling effervescent tablets have better disintegration than capsules Effect, faster dissolution rate, which is of great significance for reducing the discomfort of use and improving the effect of use.

Embodiment 3

[0020] Example Three Fuyanling Effervescent Tablet Foaming Test

[0021] 1. Instrument: 25ml measuring cylinder, water bath

[0022] 2. Experimental drug: 12 tablets of this product, divided into 6 groups, 2 tablets in each group.

[0023] 3. Test method: Take a 25ml measuring cylinder, put it in a water bath, add 3ml of water at 37±1℃ precisely, add 2 tablets of this product, wait for the bubbles to stop, and read the number of milliliters of foam.

[0024] serial number

[0025] 5. Conclusion: The foaming volume of Fuyanling Effervescent Tablets is ≥15ml / 2 tablets, and the foaming performance is good, which is helpful for increasing and prolonging the contact area and time between the drug and the folds of vaginal and cervical mucosa, and maximizing the therapeutic effect. larger meaning.

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Abstract

The present invention relates to a Chinese medicine compound preparation and its preparation process. Its prescription is formed from the Chinese medicinal materials of beauty-berry leaf, camphor, stemona root, agrimony, borneol, flavescent sophora root, alum and cnidium seed and the Western medicines of benzalkonium bromide and boric acid, and its dosage form is an effervescent tablet containing two components of acid and alkali, in which acid is citric acid, and alkali is sodium hydrogen carbonate. The Chinese medicine compound preparation has the advantages of quick resolution speed and increasing and prolonging the contacted are and time of medicine and rugose region of vaginal and cervical muscous membrane at the same time of producing foam.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation and a preparation process thereof. Background technique [0002] Fuyanling Capsule is a gynecological Chinese patent medicine independently developed by Zhejiang Kelisi'an Pharmaceutical Co., Ltd. It has a unique formula, high-quality materials, exquisite workmanship and remarkable curative effect. It won the Excellent Product Award of Zhejiang Province and is deeply loved by patients. However, because it is a capsule, the capsule shell takes a long time to melt, which causes discomfort to the patient and affects the therapeutic effect. Contents of the invention [0003] For this reason, Zhejiang Kelisi'an Pharmaceutical Co., Ltd. has developed a new dosage form - Fuyanling Effervescent Tablets, which has the advantages of fast drug dissolution, and increases and prolongs the contact area between the drug and the folds of the vaginal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P15/02A61P31/02A61P31/10
Inventor 马越峰谢元德杨建科
Owner 浙江南洋药业有限公司
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