Coral hydroxyapatite artificial bone with ª‰type tricalcium phosphate coating and its preparation

A technology of coral hydroxyapatite and tricalcium phosphate, which is applied in medical science, prostheses, coatings, etc., can solve problems such as the influence of bone conduction, difficulty in preparing three-dimensional structures, etc., and achieve no industrial pollution and simple process operation , toughness and strength improvement effect

Active Publication Date: 2004-11-17
北京市意华健科贸有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to prepare the material prepared by artificial foaming into pores into a three-dimensional structure with pores connected to human bones, which greatly affects its osteoconductivity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] Reaction raw materials: coral hydroxyapatite, diammonium hydrogen phosphate, deionized water.

[0022] Procedure and conditions: 9 grams of coral hydroxyapatite with an average pore size of 200 μm were uniformly immersed in a solution of 0.2 mol / L diammonium hydrogen phosphate. After taking it out and drying it, put it in a heating furnace to react at a temperature of 900° C. for 3 hours, then gradually cool it down, take out the solid product and wash, dry and sterilize it.

[0023] The product is analyzed by X-ray powder diffraction spectrum, and the content of the beta-type tricalcium phosphate is 15%, the thickness is about 5 μm, and the thickness ranges from 1 μm to 30 μm.

example 2

[0025] Reaction raw materials: coral hydroxyapatite, ammonium dihydrogen phosphate, deionized water.

[0026] Procedures and conditions: 8 grams of coral hydroxyapatite with an average pore size of 200 μm were uniformly immersed in a solution of 1 mol / L ammonium dihydrogen phosphate. After taking it out and drying it, put it in a heating furnace to react at a temperature of 850°C for 4 hours, then gradually cool it down, take out the solid product and wash, dry and sterilize it.

[0027] The product is analyzed by X-ray powder diffraction spectrum, and the content of the beta-type tricalcium phosphate is 50%, the average thickness is 15 μm, and the thickness range is 1 μm to 52 μm.

example 3

[0029] Reaction raw materials: coral hydroxyapatite, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, deionized water.

[0030] Procedures and conditions: 10 grams of coral hydroxyapatite with an average pore size of 200 μm was uniformly immersed in a mixed solution of 0.5 mol / L diammonium hydrogen phosphate and 0.5 mol / L ammonium dihydrogen phosphate. After taking it out and drying it, put it in a heating furnace to react at a temperature of 900° C. for 3 hours, then gradually cool it down, take out the solid product and wash, dry and sterilize it.

[0031] The product is analyzed by X-ray powder diffraction spectrum, and the content of the β-type tricalcium phosphate is 40%, the average thickness is 16 μm, and the thickness range is 1 μm to 85 μm.

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Abstract

The invention relates to a coral hydroxyapatite artificial bone whose surface is beta-type tricalcium phosphate, and its preparing process comprising, at a given temperature, soaking coral hydroxyapatite in phosphoric acid, phosphates or their mixed solution for some time, and heating again to proceed conversion reaction.

Description

Technical field: [0001] The invention relates to a coral hydroxyapatite (CHA) artificial bone whose surface is β-type tricalcium phosphate (β-TCP) and a preparation method thereof. technical background: [0002] Hydroxyapatite (HA) has excellent biocompatibility and bone affinity, and is currently an excellent orthopedic implant material commonly used in clinical practice. Hydroxyapatite is very stable in the human body, but its solubility is extremely small, so it is slowly absorbed by the body. β-tricalcium phosphate (β-TCP) bone implant material also has excellent biocompatibility and bone affinity, but absorbs too fast and is not suitable for new bone growth. [0003] If the human body absorbs the artificial bone too quickly, new bone defects will be formed; on the contrary, if it is too slow, the healing time will be delayed. Porous HA / TCP dual-phase ceramics is a composite bone repair material obtained by mixing HA powder and TCP powder, heat-treating, foaming into p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/32
Inventor 宋正孝陈德夫范丽娟
Owner 北京市意华健科贸有限责任公司
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