Method of activating lvier stem cell

A technology of liver stem cells and oval cells, applied in the field of activation of liver stem cells, can solve problems such as acetamidofluorene damage and liver parenchymal cell necrosis
CN1548528AInactive Publication Date: 2004-11-24INST OF ZOOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2004-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The method of activating liver stem cell includes combined ethyl thioamino butyric acid and partial liver excision method, and conventional collagenase digesting and density gradient centrifugation method to separate oval liver cell. The method of the present invention can activate liver stem cell in short period without damage, and present invention makes it possible to provide great amount of cell for the preclinical research of liver stem cell and preclinical animal transplantation experiment.
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Description

technical field

[0001] The present invention relates to hepatic stem cells, in particular to a method for activating hepatic stem cells. technical background

[0002] China is a big country with liver disease. At present, there are more than 20 million chronic hepatitis B patients, and more than 500,000 people die each year from advanced liver cirrhosis or liver cancer. Liver transplantation is an effective means to solve advanced liver organic diseases, but the biggest problem facing liver transplantation is the shortage of organ sources. Take the U.S., where there are relatively few liver diseases, as an example. About 18,500 people are ready to receive liver transplants every year, but less than a quarter of the patients are expected to receive donor liver transplants. In Asia, there are more than 100,000 patients with severe liver cirrhosis . One of the important ways to solve the severe shortage of donor liver organs is to carry out hepatic stem cell transplantation,...

Claims

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