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Collagen material and its production process

A technology of collagen and intermediate materials, applied in textiles, single-component protein rayon, fiber chemical characteristics, etc., can solve problems such as difficulty in use

Inactive Publication Date: 2004-12-01
清水庆彦 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyethylene glycol acid causes strong fracture healing and is difficult to use for automatic suturing due to opacity
And bovine pericardium also has the above-mentioned shortcomings

Method used

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  • Collagen material and its production process
  • Collagen material and its production process
  • Collagen material and its production process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Using collagen taken from pig skin, a 1N hydrochloric acid solution of collagen with a concentration of 1% by weight was prepared and poured into a vessel to form collagen solution layers of 6, 12, and 18 mm thick. It was frozen at -20°C for 24 hours, and then freeze-dried at -80°C for 24 hours. Use a press to 200kg / cm 2 The pressure is heat compressed at room temperature for 15 seconds to form layers of about 0.2, 0.3 and 0.5 thickness respectively. The compressed collagen layer prepared with the above-mentioned collagen as a raw material is immersed in a collagen solution and air-dried. This immersion and air-drying process was repeated 5 or 10 times, and then the thermal crosslinking treatment was performed at 140°C for 24 hours under vacuum to obtain the collagen material of the present invention.

[0032] Regarding the collagen material of the present invention prepared as described above, the supporting tension and breaking tension of one point of the collagen materia...

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PUM

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Abstract

The present invention relates to an ultra-fine fibrous collagen obtainable by freezing a1N hydrochloric acid solution of collagen at about -10 to -196 DEG C for at least about 6 hours followed by freeze-drying the frozen collagen solution in a vacuum.

Description

[0001] This application is a divisional application. The application number of the parent application: 97199925.2, the filing date: 1997.11.19, the title of the invention: collagen material and its preparation method. Technical field [0002] The present invention relates to a collagen material, a filamentous material containing the collagen material, a method for manufacturing these materials, and a medical material containing the collagen material, especially a medical substitute film composed of the medical material. The above-mentioned collagen material is composed of a laminated body in which a collagen ultrafine fibrous nonwoven fabric-like multilayer body is sandwiched by a non-fibrillated collagen layer. Background technique [0003] Among the various raw materials used as medical materials, animal-derived collagen is superior in biological affinity and tissue adaptability, and has low antigenicity. It has the effect of promoting the differentiation and proliferation of pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61F2/00A61L27/24A61L31/04C08L89/06
CPCY10S623/924A61L27/24A61F2310/00365Y10S623/925Y10S623/909C08L89/06Y10S128/08A61L31/044Y10T442/2525A61L27/00
Inventor 清水庆彦
Owner 清水庆彦