Preparing process of medicinal composition for treating acute and chronic bronchitis

A technology for chronic bronchitis and composition, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of uncontrollable preparation quality, inconvenient storage and taking, backward technology and dosage form, etc. Control quality, improve particle properties, and satisfy clinical absorption effect

Inactive Publication Date: 2004-12-29
SICHUAN RENDE PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

"Its technology and dosage form are backward, it is not convenient to store and take, t

Method used

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  • Preparing process of medicinal composition for treating acute and chronic bronchitis

Examples

Experimental program
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Example Embodiment

[0026] Example 1 Preparation of the pharmaceutical composition capsule of the present invention

[0027] Ephedra 283g, licorice 226g, bitter almonds (fried) 142g, pinellia 113g, scutellaria (wine steamed) 85g, araceae (made) 85g, perilla (fried) 85g, mint 85g, platycodon 85g, zhebei 85g Mulberry peel 85g, tangerine peel 85g, aster 57g;

[0028] The above 13 flavors, tangerine peel, mint and 8 times the amount of water are added to distill the volatile oil for 6 hours. The volatile oil is collected, filtered, and the filtrate and medicine residue are used for later use. Ephedra, Pinellia ternata, and Fritillaria vulgaris were extracted with 8 times the amount of 60% ethanol (adjusted with 20% hydrochloric acid to adjust PH=5) for 3 times at reflux, 1 hour each time, filtered (300 mesh), combined the filtrate, and recovered under reduced pressure The relative density of ethanol to clear ointment is 1.06~1.08 (60°C) for use; medicine residue is for use. Licorice, bitter almonds (stir...

Example Embodiment

[0030] Example 2 Preparation of the pharmaceutical composition tablet of the present invention

[0031] Ephedra 466g, licorice 80~372g, fried bitter almonds 50~234g, French pinellia 40~186g, wine steamed skullcap 30~140g, Araceae 30~140g, fried perilla 30~140g, mint 30~140g, platycodon 30 ~140g, Fritillaria persicae 30~140g, Mulberry peel 30~140g, Tangerine peel 30~140g, Aster 20~94g;

[0032] The above 13 flavors, tangerine peel, mint and 8 times the amount of water are added to distill the volatile oil for 6 hours. The volatile oil is collected, filtered, and the filtrate and medicine residue are used for later use. Ephedra, Pinellia ternata, and Fritillaria vulgaris were extracted with 8 times the amount of 60% ethanol (adjusted with 20% hydrochloric acid to adjust PH=5) for 3 times at reflux, 1 hour each time, filtered (300 mesh), combined the filtrate, and recovered under reduced pressure The relative density of ethanol to clear ointment is 1.06~1.08 (60°C) for use; medicine ...

Example Embodiment

[0033] Example 3 Content control of index components of the pharmaceutical composition of the present invention

[0034] Accurately weigh about 1.5 g of the drug content of the present invention prepared in Example 1, put it in a 25 ml measuring flask, add an appropriate amount of methanol, sonicate for 60 minutes, let cool, dilute with methanol to the mark, shake well, filter, and discard the original For the filtrate, accurately measure 10ml of the subsequent filtrate, place it on a water bath and evaporate to dryness, add methanol to the residue to dissolve it, and quantitatively transfer it to a 5ml volumetric flask, dilute to the mark, shake well, and use it as the test solution. Take another ephedrine hydrochloride reference substance, add methanol to make a solution containing 1.5mg per 1ml, as the reference substance solution. According to thin-layer chromatography (Chinese Pharmacopoeia 2000 edition, an appendix IVB) test, draw 1μl and 2μl of the reference solution and 2μ...

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Abstract

The medicine composition for treating acute and chronic bronchitis is prepared with Chinese ephedra, licorice, almond, pinellia tuber, skullcap root and other eight kinds of Chinese medicinal materials, and through certain preparation process. The medicine composition has high effective component content, small dosage, and ephedrine selected as quality index component to make the medicine composition safe, effective, stable and controllable. The present invention provides one new clinically selected material.

Description

technical field [0001] The invention relates to a preparation method of a medicinal composition for treating acute and chronic bronchitis, in particular to a preparation method of a medicinal composition using traditional Chinese medicine as a raw material, belonging to the field of traditional Chinese medicine. Background technique [0002] Acute trachea and bronchitis are common clinical diseases and frequently-occurring diseases, which are caused by factors such as viral or bacterial infection, physical and chemical stimulation, and allergic reactions. As long as they are actively treated, most patients can recover in a short period of time. Unhealed or recurrent outbreaks can develop into chronic bronchitis. Chronic bronchitis is a chronic non-specific inflammatory syndrome, which is generally caused by internal factors such as local defense of the respiratory tract, decreased immune function, autonomic nerve dysfunction, allergies, and genetics, plus external factors su...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/20A61K9/48A61P11/00
Inventor 陈仁德张廷模
Owner SICHUAN RENDE PHARMA
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