Radix scutellariae extract freeze-dried powder injection and its preparing method

The technology of Scutellaria baicalensis extract and freeze-dried powder injection is applied in the field of freeze-dried powder injection of Scutellaria baicalensis extract and its preparation, which can solve the problem that the Scutellaria baicalensis extract cannot be made into injection and the like, and achieve precise curative effect, good stability and easy storage. Effect

Inactive Publication Date: 2005-01-12
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the deficiencies in the existing traditional Chinese medicine preparation technology, and solve the problem that the extract of Scutellaria baicalensis cannot be made into injections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prepare a 10% aqueous solution with medicinal L-arginine and water for injection. After ultrasonic deoxygenation, take 1000ml, add 33g of baicalein for injection, stir and heat at 60°C to dissolve it, continue to add 6g of filler mannitol, and then Add an appropriate amount of activated carbon for needles, stir at 60°C for 30 minutes, filter with a No. 4 sand plug, and filter with a 0.22μф300mm sterile membrane under pressure. The bottle is divided into about 2ml, and then freeze-dried to make 500 bottles of finished product, each bottle containing 60mg baicalein.

Embodiment 2

[0035] Prepare a 0.6% aqueous solution with analytically pure sodium hydroxide and water for injection, take 1000ml after ultrasonic deoxygenation, add 5g of sodium ascorbate, then add 16.5g of baicalein for injection and 16.5g of baicalin for injection, stir and heat at 80°C to dissolve , then add an appropriate amount of activated carbon for needles, stir at 80°C for 20 minutes, filter with a No. 4 sand plug, and filter with a 0.22μф300mm sterile membrane under pressure. , each bottle is divided into about 2ml, and then freeze-dried to make 500 bottles of finished products. The specification of each bottle is to contain 60 mg of Scutellaria baicalensis extract (30 mg of baicalein and baicalin).

Embodiment 3

[0037] Make a 15% aqueous solution with medicinal arginine and water for injection, take 1000ml after ultrasonic deoxygenation, add 5g of sodium ascorbate and 0.5g of disodium EDTA to dissolve, then add 33g of baicalein for injection and 33g of baicalin for injection, and stir Heat at 70°C to dissolve it, then add appropriate amount of activated carbon for needles, stir at 90°C for 10 minutes, filter with No. Pack in 20ml cillin bottles, each bottle is divided into about 4ml, and then freeze-dried to make 500 bottles of finished products, each bottle specification is to contain 120mg of Scutellaria baicalensis extract (60mg each of baicalein and baicalin).

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PUM

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Abstract

A freeze-dried powder injection of the mixture of scutellarin and scutelloside extracted from scutellaria root features high stability. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to the freeze-dried powder injection of scutellaria baicalensis extract extracted from scutellaria baicalensis and a preparation method thereof. Background technique [0002] The traditional Chinese medicine Scutellaria baicalensis Georgi is the root of Scutellaria baicalensis Georgi, which has the functions of clearing away heat and dampness, purging fire and detoxification, stopping bleeding and preventing miscarriage. [0003] Baicalein and Baicalin are extracts extracted from the dried roots of Scutellaria baicalensis. They have exact chemical structures, and their structural formulas are: [0004] R=H baicalein R=glucuronic acid baicalin [0005] Studies in recent years have found that these two extracts of Scutellaria baicalensis have antibacterial and antiviral effects, especially baicalein has more liver protection, gallbladder diuresis, free radical scavenging ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/7048A61P1/16A61P9/12A61P31/00A61P35/00
Inventor 潘福生王新华方国林叶杉胡凯
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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