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Sodium hyaluronate nasal cavity anti-adhesion and hemostatic flushing solution containing Tianqi active ingredient and its preparation method and application

A technology of sodium hyaluronate and active ingredients, applied in the field of biomedical engineering materials, can solve the problems that have not been reported in the application, and achieve the effects of good bioadhesion, inhibition of bleeding, and long release cycle

Active Publication Date: 2021-03-09
GUANGDONG GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, sodium hyaluronate nasal cavity anti-adhesion, hemostatic irrigation solution containing Tianqi active ingredient and its application have not been reported

Method used

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  • Sodium hyaluronate nasal cavity anti-adhesion and hemostatic flushing solution containing Tianqi active ingredient and its preparation method and application
  • Sodium hyaluronate nasal cavity anti-adhesion and hemostatic flushing solution containing Tianqi active ingredient and its preparation method and application
  • Sodium hyaluronate nasal cavity anti-adhesion and hemostatic flushing solution containing Tianqi active ingredient and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: extracting the active ingredient of Tianqi

[0034] Take the dried Tianqi powder at 25°C, first soak it in ether for 30 minutes, then remove the supernatant, then take an appropriate amount of ethanol to continue soaking for 30 minutes, then air-dry it for 5 hours, add an appropriate amount of distilled water to soak for 30 minutes, ultrasonic for 1 minute and extract once, filter paper to remove the residue, Obtain the extract of Tianqi active ingredient. The preparation method of the dried Tianqi powder follows the following steps: the Tianqi powder is placed in a vacuum drying oven, and dried at 50° C. for 12 hours. The volume ratio of the ether to ethanol and distilled water is 1:1:1; the amount of ether used is calculated by adding 1 g of dry Tianqi powder per 100 ml; the ultrasonic frequency is 250 W; the filter paper pore size is 10 μ.

Embodiment 2

[0035] Embodiment 2: Extract the active ingredient of Tianqi

[0036] Take the dried Tianqi powder at 35°C, soak it in ether for 10 hours and remove the supernatant, then take an appropriate amount of ethanol to continue soaking for 20 hours, then air-dry for 48 hours, add an appropriate amount of distilled water to soak for 40 hours, ultrasonic 1 hour and extract 3 times, filter paper to remove the residue, Obtain the extract of Tianqi active ingredient. The preparation method of the dried Tianqi powder follows the following steps: the Tianqi powder is placed in a vacuum drying oven, and dried at 80° C. for 48 hours. The ultrasonic frequency is 1KW; the pore size of the filter paper is 120μ. The volume ratio of diethyl ether to ethanol and distilled water is 1:1:3; the amount of diethyl ether used is calculated by adding 10 g of dried Tianqi powder per 100 ml.

Embodiment 3

[0037] Embodiment 3: Extract the active ingredient of Tianqi

[0038] Take the dried Tianqi powder at 30°C, first soak it in ether for 5 hours, then remove the supernatant, then take an appropriate amount of ethanol to continue soaking for 10 hours, then air-dry it for 24 hours, add an appropriate amount of distilled water to soak for 20 hours, sonicate for 30 minutes and extract twice, filter paper to remove the residue, Obtain the extract of Tianqi active ingredient. The preparation method of the dried Tianqi powder follows the following steps: the Tianqi powder is placed in a vacuum drying oven, and dried at 60° C. for 36 hours. The ultrasonic frequency is 500W; the pore size of the filter paper is 80μ. The volume ratio of ether to ethanol and distilled water is 1:2:2; the amount of ether used is calculated by adding 6 g of dried Tianqi powder per 100 ml.

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Abstract

The invention discloses a sodium hyaluronate nasal cavity anti-adhesion and hemostatic flushing liquid containing the active ingredient of Tianqi, a preparation method and application thereof, and belongs to the field of biomedical engineering materials. The preparation method comprises (1) extraction of the active ingredient of Tianqi and (2) preparation of sodium hyaluronate nasal cavity washing solution containing the active ingredient of Tianqi. The method of the invention is easy to operate, and the obtained flushing solution has good biocompatibility and biodegradability, has little metabolic toxicity, greatly improves the bioavailability of the drug, is an ideal material for preventing adhesion, and has a high purity of the active ingredient of Tianqi High, can effectively inhibit bleeding and provide support for its application in the preparation of biomedical engineering materials.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, and in particular relates to a sodium hyaluronate anti-adhesion and hemostatic flushing solution containing the active ingredient of Tianqi and its preparation method and application. Background technique [0002] With the popularization of nasal endoscopy, nasal endoscopic surgery has become a routine operation in otolaryngology. Nasal adhesion is the most common complication after nasal endoscopic surgery (European Archives of Oto-Rhino-Laryngology 2017;274: 181- 188.), affect the physiological function of the nasal cavity, and significantly reduce the effect of surgery and treatment. Sodium hyaluronate is a high-molecular substance widely present in various tissues of humans and animals. It was first isolated and extracted from the vitreous humor of bovine eyes by Meyer and Palmer in 1934. It is a highly viscous substance with very good biological properties. Compatibility (Bio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K36/23A61K47/36A61P41/00A61P11/02A61P7/04A61K31/728
CPCA61K9/0043A61K31/728A61K36/23A61K36/258A61K47/36A61K2236/331A61K2236/35A61K2236/39A61K2300/00
Inventor 刘涛陈少华李波波张思毅吴佩娜季敏娴马栋
Owner GUANGDONG GENERAL HOSPITAL
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