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Compound diisopropylamine dichloroacetate transfusion liquid

A compound technology of diisopropylamine dichloroacetate, which is applied in the field of medicine, can solve problems such as cross-contamination and inconvenient clinical use of medical staff, and achieve the effect of quick onset and convenient operation

Inactive Publication Date: 2005-01-26
肖广常 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the formulations of compound diisopropylamine dichloroacetate on the market are tablets and injections. However, in clinical application, compound diisopropylamine dichloroacetate often needs to be compatible with normal saline or glucose solution for intravenous infusion. It brings inconvenience to the clinical use, and also makes the compound diisopropylamine dichloroacetate injection easy to cause cross-contamination in the process of compatible use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: compound diisopropylamine dichloroacetate infusion, the components are as follows (all are percentages by weight):

[0013] Diisopropylamine dichloroacetate 0.059%

[0014] Sodium Gluconate 0.056%

[0015] Glycerin 0.005%

[0016] Sodium chloride 0.892%

[0017] Water for Injection 98.988%

[0018] The preparation method is as follows:

[0019] (1) The infusion bottle, rubber stopper, and polyester film are treated according to the routine requirements for injections, and they are set aside.

[0020] (2) Preparation of liquid medicine:

[0021] a. Weigh 900g of sodium chloride in the liquid mixing tank, add 50000g of water for injection and stir to dissolve. Add 20g of activated carbon for needles, heat and stir for carbon adsorption for 30 minutes, filter and decarbonize with a titanium filter stick, add water for injection to the full amount, and stir well.

[0022] b. Weigh 60g of diisopropylamine dichloroacetate, 57g of sodium gluconate, and 5g ...

Embodiment 2

[0028] Embodiment 2: compound diisopropylamine dichloroacetate infusion, the components are as follows (both are by weight):

[0029] Diisopropylamine dichloroacetate 0.426%

[0030] Sodium Gluconate 0.405%

[0031] Glucose 25%

[0032] Water for injection 74.169%

[0033] The preparation method is the same as in Example 1.

Embodiment 3

[0034] Embodiment 3: compound diisopropylamine dichloroacetate infusion, the components are as follows (both are percentages by weight):

[0035] Diisopropylamine dichloroacetate 0.128%

[0036] Sodium Gluconate 0.122%

[0037] Sorbitol 0.160%

[0038] Edetate Disodium 0.008%

[0039] Mannitol 20%

[0040] Water for injection 79.582%

[0041] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a compound diisopropylamine dichloroacetate transfusion liquid, which comprises disopropylamine dchloroacetate 0.002-5%, sodium gluconate .002-4.8%, osmoregulation agent 0.8-75%, water for injection 20-99%.

Description

(1) Technical field [0001] The invention relates to a compound diisopropylamine dichloroacetate transfusion solution, which belongs to the technical field of medicine. (2) Background technology [0002] Hepatitis disease has a wide range of infections and a high incidence. According to statistics, there are more than 120 million patients with various liver diseases in my country, and everyone has such patients in their life circle. With the improvement of living standards, dietary structure and lifestyle have changed greatly, and the incidence of some "modern diseases" and "rich people's diseases" is getting higher and higher. Fatty liver is the most typical one. The incidence of fatty liver in Shenzhen is gradually increasing, and fatty liver has become the second major liver disease that threatens the health of citizens, second only to viral hepatitis. Professor Ye Hongjun pointed out that in Shenzhen, more than 10% of people suffer from this disease, and the detection ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/195A61P1/16A61P31/12
Inventor 肖广常张颖
Owner 肖广常
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