Nasal spray for treating headache and hemicrania and its preparation method

A nasal spray and migraine technology, which is applied in the directions of aerosol delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of uneven distribution of medicinal liquid in the nasal cavity, complex production process, inaccurate quantitative and other problems, Achieve the effect of not easy to run off, high bioavailability and uniform distribution

Inactive Publication Date: 2005-02-16
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage form is simple to configure and does not require a special drug delivery device. It is especially suitable for a small amount of self-made application by medical staff in clinical practice. Loss, etc.; aerosol is better in terms ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Firstly, the active ingredients in Chuanxiong, Asarum, and Peppermint were extracted by steam distillation extraction method to obtain Chuanxiong extract, Asarum extract, and Peppermint extract.

[0045] Drug formula: 3 parts of Chuanxiong extract

[0046] Asarum extract 5 parts

[0047] 2 parts peppermint extract

[0048] Excipients: one part each of Tween, Span, glycerol monostearate, and sucrose fatty acid ester.

[0049] Dissolve the excipients in the solvent absolute ethanol, then add the extracts of Rhizoma Chuanxiong, Asarum and Peppermint according to the above drug formula, mix well, pour into the nasal cavity spray pump of German Pfeiffer company, and prepare the nasal cavity spray.

Embodiment 2

[0050] Example 2: Firstly, the active ingredients in Chuanxiong, Asarum, and Peppermint were extracted by supercritical fluid extraction to obtain Chuanxiong extract, Asarum extract, and Peppermint extract.

[0051] Drug formula: 5 parts of Chuanxiong extract

[0052]Asarum extract 3 parts

[0053] 2 parts peppermint extract

[0054] Excipients: one part each of Tween, Span, glycerol monostearate, and sucrose fatty acid ester.

[0055] Dissolve the excipients in the solvent absolute ethanol, then add the extracts of Rhizoma Chuanxiong, Asarum and Peppermint according to the above drug formula, mix well, pour into the nasal cavity spray pump of German Pfeiffer company, and prepare the nasal cavity spray.

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PUM

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Abstract

The invention relates to a nose cavity spraying agent for curing headache and migraine and its manufacutirng method. The prescription includes medicine effective ingredients and accessories, the effective ingredients of the medicine is made up of 1-10 shares of chuanxiong rhizome extract, asarum extract and mint extract, the extraction of the effective ingredient may be steam distilling extract method or supercritical fluid extraction method, then the accessories are dissolved in the solution waterless alcohol, then adds in the effective ingredients of each medicine, they are blended fully and poured into the nose cavity spraying pump, the nose cavity spraying agent uses the rich mucous and vessels in the nose cavity, the absorption of the medicine is quick, the biology utilization rate is high, the effect is prominent, and it has no propellant, it does not use pressure resisting container, the atomization drop is tiny, it is even in the nose cavity.

Description

technical field [0001] The invention relates to a drug dosage form, in particular to a nasal cavity administration dosage form for treating headache and migraine. Background technique [0002] Headache is one of the common clinical symptoms, and every adult may have experienced it in a mild or severe manner. Specifically, headache refers to pain or non-painful discomfort in a certain part of the face or head and neck, inside or outside the skull. It has many causes, some of which are serious and fatal, but the etiological diagnosis often causes difficulties. At present, those with headache as the main symptom can be found in infectious febrile diseases, hypertension, intracranial diseases, neurosis, concussion and migraine. Migraine usually occurs in adolescence, and some patients have a family history, which is mostly induced by fatigue, emotional factors, and menstrual periods. Currently in Italy, nearly one in six people suffer from migraines. ...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/4965A61P25/04A61P25/06
Inventor 陈锡林王平李丽邓凤君吴志卿刘珺黄方吴恩国金忠其吕祖平葛彩华
Owner ZHEJIANG UNIV OF TECH
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