Vitellus immune globulin for preventing prawn virus, tis preparing method and use thereof

Abstract

This invention refers to cultivating aquatic animal cultivating and, especially, to vitelline immune globulin' s preparation, which is capable to prevent prawn virus disease. The feature is that: preparing a kind mono-antigen and composite antigen with one or several kinds of inactivate strain / attenuated strain / gene subunit immunogen / nucleic acid immunogen, which belong to prawn leucoderma syndrome virus. The egg avian are uaed as biological reactors, immunity obtaining resisting prawn leucoderma syndrome a specificity LgY, which is alone or together with peptidoglycan, probiotics or Chinese herbs medicine, are capable of being active component of feedstuff additives, medicinal dipping agent, or prawn pool dousing agent to prevent from prawn diseases. The advantages are IgY having effect through passive immunity mechanism to inhibit or kill the virus directly and increase prawn 's immunological competence. It has obvious effect in treating leucoderma syndrome for prawn, and safety, environment protecting, convenient etc.

Description

technical field [0001] The invention belongs to the field of biotechnology, relates to the technical field of aquatic animal breeding, and in particular relates to a yolk immunoglobulin (IgY) for preventing and treating prawn virus disease and a preparation method thereof. The IgY can be used as a feed additive or a medicine bathing agent or the active ingredient of the splashing agent to control the white spot syndrome of prawns. Background technique [0002] my country's prawn farming started in the late 1970s. The continuous improvement and perfection of aquaculture production technology made it quickly become one of the pillar industries of the mariculture industry. The density of stocking, coupled with the continuous deterioration of the ecological environment for farming, has made shrimp diseases, especially viral diseases of shrimps, an important factor hindering the development of this industry. From 1993 to 1994, prawn virus disease raged across my country's north a...

AI Technical Summary

Problems solved by technology

[0009] 1. The pathogen of prawn white spot syndrome is a type of virus. There are differences in the white spot disease virus infected by different hosts in different regions. Only one kind of white spot syndrome virus is selected to prepare the antigen. It cannot be applied to infections caused by other virus strains, the actual application range is narrowed, and the effect of inhibiting and killing viruses is weakened

[0010] 2. The nucleic acid immunogen is made without using the white spot syndrome virus gene or its antigenic determinant gene, which brings disadvantages such as uneven antibody titer produced by immunized poultry, unstable yield, and reduced practical application effect

[0011] 3. Only IgY is used as the only active ingredient for the prevention and treatment of white spot syndrome in prawns. Not only the dosage is increased, but the immunity of the infected prawns is reduced, which leads to the entry of other pathogenic microorganisms, but the IgY cannot effectively inhibit the water body or These pathogenic microorganisms existing inside the shrimp body cannot achieve the best therapeutic effect